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Reduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder

DC FieldValueLanguage
dc.contributor.author김어수-
dc.contributor.author김재진-
dc.contributor.author정영철-
dc.contributor.author조현상-
dc.date.accessioned2015-04-24T17:20:46Z-
dc.date.available2015-04-24T17:20:46Z-
dc.date.issued2009-
dc.identifier.issn0278-5846-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105225-
dc.description.abstractSocial cognition entails both cognitive and affective processing, and impairments in both have accounted for residual symptoms of bipolar disorder (BD). However, there has been a lack of studies identifying neural substrates responsible for social cognitive difficulties in BD patients. Fourteen euthymic BD patients and 14 healthy normal controls underwent functional MRI while performing a virtual reality social cognition task, which incorporated both cognitive and emotional dimensions, simulating real-world social situations. During the scanning, subjects tried to guess (attribute) possible reasons for expressed emotion of virtual humans (avatars) while viewing their facial expressions, just after observing their verbal and nonverbal (facial) expressions which were emotionally valenced (happy, angry and neutral). BD patients compared to normal controls showed delayed reaction times in emotional conditions, with comparable response accuracy. Healthy normal controls activated the right anterior cingulate cortex, inferior frontal, and insular cortex in emotional conditions contrasted with neutral control conditions, that is, the regions that have been related to empathic processes during viewing others' emotional expression. Relative to normal controls, BD patients showed reduced activations in the 'mirror neuron system', including the right inferior frontal cortex, premotor cortex, and insula, mainly in angry or happy condition. These results may suggest that, even during euthymic state, BD patients have difficulties in recruiting brain regions for the utilization of emotional cues as a means for understanding others. Clinical attention should be paid to emotion-related residual symptoms to help improve social outcomes in these patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1409~1416-
dc.relation.isPartOfPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBipolar Disorder/pathology*-
dc.subject.MESHBipolar Disorder/physiopathology*-
dc.subject.MESHBrain Mapping-
dc.subject.MESHCerebral Cortex/blood supply-
dc.subject.MESHCerebral Cortex/pathology*-
dc.subject.MESHCognition/physiology*-
dc.subject.MESHEmotions/physiology-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHOxygen/blood-
dc.subject.MESHSocial Behavior*-
dc.subject.MESHUser-Computer Interface-
dc.subject.MESHYoung Adult-
dc.titleReduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorEosu Kim-
dc.contributor.googleauthorYoung-Chul Jung-
dc.contributor.googleauthorJeonghun Ku-
dc.contributor.googleauthorJae-Jin Kim-
dc.contributor.googleauthorHyeongrae Lee-
dc.contributor.googleauthorSo Young Kim-
dc.contributor.googleauthorSun I. Kim-
dc.contributor.googleauthorHyun-Sang Cho-
dc.identifier.doi10.1016/j.pnpbp.2009.07.019-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03656-
dc.contributor.localIdA00686-
dc.contributor.localIdA00870-
dc.contributor.localIdA03928-
dc.relation.journalcodeJ02554-
dc.identifier.eissn1878-4216-
dc.identifier.pmid19632283-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0278584609002474-
dc.subject.keywordBipolar disorder-
dc.subject.keywordEmotional processing-
dc.subject.keywordFunctional MRI-
dc.subject.keywordMirror neuron system-
dc.subject.keywordSocial cognition-
dc.subject.keywordVirtual reality-
dc.contributor.alternativeNameKim, Eo Su-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNameJung, Young Chul-
dc.contributor.alternativeNameCho, Hyun Sang-
dc.contributor.affiliatedAuthorJung, Young Chul-
dc.contributor.affiliatedAuthorKim, Eo Su-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorCho, Hyun Sang-
dc.citation.volume33-
dc.citation.number8-
dc.citation.startPage1409-
dc.citation.endPage1416-
dc.identifier.bibliographicCitationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, Vol.33(8) : 1409-1416, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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