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비소세포 폐암환자에서 Docetaxel 투여 중 발생한 아급성 피부 홍반루푸스 1예

Other Titles
 A Case of Docetaxel Induced Subacute Cutaneous Lupus Erythematosus 
Authors
 신정아  ;  허철웅  ;  권지은  ;  김형중  ;  안철민  ;  장윤수 
Citation
 Tuberculosis and Respiratory Diseases, Vol.66(5) : 380-384, 2009 
Journal Title
 Tuberculosis and Respiratory Diseases 
ISSN
 3780-0066 
Issue Date
2009
Abstract
Drug-induced subacute cutaneous lupus erythematosus (SCLE) is associated with use of the following classes of medications: anti-hypertensives, anti-cholesterolemia, anti-psychotics, and anti-inflammatory drugs. Docetaxel is an anti-neoplastic agent, which is widely used for treatment of non-small cell lung cancer. Few cases of docetaxel-induced SCLE have been reported in the medical literature. Here, we report the case of a 58-year-old female patient who developed drug-induced SCLE after administration of docetaxel. After 4 cycles of chemotherapy with docetaxel and cisplatin, erythematous skin eruptions developed on the patient's face. Skin biopsies of the eruptions were remarkable for interfacing dermatitis with basement membrane thickening. Immunofluorescent study revealed characteristic features of SCLE, including granular deposition of IgM, C3, and apoptotic bodies along the basement membrane. The skin eruptions resolved gradually after cessation of drug and with the use of topical corticosteroids.
Files in This Item:
T200903610.pdf Download
DOI
10.4046/trd.2009.66.5.380
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
권지은(Kwon, Ji Eun)
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
안철민(Ahn, Chul Min)
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105207
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