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비소세포 폐암환자에서 Docetaxel 투여 중 발생한 아급성 피부 홍반루푸스 1예

Other Titles
 A Case of Docetaxel Induced Subacute Cutaneous Lupus Erythematosus 
 신정아  ;  허철웅  ;  권지은  ;  김형중  ;  안철민  ;  장윤수 
 Tuberculosis and Respiratory Diseases, Vol.66(5) : 380-384, 2009 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
Subacute cutaneous lupus erythematosus ; Drug-induced lupus erythematosus ; Non-small-cell lung carcinoma ; Docetaxel
Drug-induced subacute cutaneous lupus erythematosus (SCLE) is associated with use of the following classes of medications: anti-hypertensives, anti-cholesterolemia, anti-psychotics, and anti-inflammatory drugs. Docetaxel is an anti-neoplastic agent, which is widely used for treatment of non-small cell lung cancer. Few cases of docetaxel-induced SCLE have been reported in the medical literature. Here, we report the case of a 58-year-old female patient who developed drug-induced SCLE after administration of docetaxel. After 4 cycles of chemotherapy with docetaxel and cisplatin, erythematous skin eruptions developed on the patient's face. Skin biopsies of the eruptions were remarkable for interfacing dermatitis with basement membrane thickening. Immunofluorescent study revealed characteristic features of SCLE, including granular deposition of IgM, C3, and apoptotic bodies along the basement membrane. The skin eruptions resolved gradually after cessation of drug and with the use of topical corticosteroids.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ji Eun(권지은)
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Ahn, Chul Min(안철민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
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