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Association of Insulin Receptor Substrate-1 G972R Variant with Non-small Cell Lung Cancer Risk.

Authors
 Chang Youl Lee  ;  Chul Min Ahn  ;  Jeong Hee Jeon  ;  Hyung Jung Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Sung Kyu Kim  ;  Yoon Soo Chang 
Citation
 Tuberculosis and Respiratory Diseases, Vol.67(1) : 8-13, 2009 
Journal Title
 Tuberculosis and Respiratory Diseases 
ISSN
 3780-0066 
Issue Date
2009
Abstract
BACKGROUND: The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3'-kinase (PI3K) pathway. IRS-1 activation of the (PI3K) pathway regulates IGF-mediated survival, enhancement of cellular motility and apoptosis. Therefore, we attempted to ascertain whether IRS-1 genetic variations affect an individual's risk for non-small cell lung cancer (NSCLC). METHODS: Two-hundred and eighteen subjects, either diagnosed with NSCLC or control subjects, were matched by age, gender and smoking status. Genomic DNA from each subject was amplified by PCR and analyzed according to the restriction fragment length polymorphism (RFLP) profile to detect the IRS-1 G972R polymorphism. RESULTS: The frequencies of each polymorphic variation, in the control population, were as follows: GG=103 (94.5%) and GR=6 (5.5%); for the NSCLC subjects, the genotypic frequencies were as follows: GG=106 (97.2%) and GR=3 (2.8%). We could not demonstrate statistically significant differences in the genotypic distribution between the NSCLC and the control subjects (p=0.499, Fisher's Exact test). The relative risk of NSCLC, associated with the IRS-1 G972R polymorphic variation, was 1.028 (95% CI; 0.63~9.90). In addition, we found no differences between polymorphic variants with regard to the histological subtype of NSCLC. CONCLUSION: We did not observe any noteworthy differences in the frequency of the IRS-1 G972R polymorphism in NSCLC patients, compared to control subjects. These results suggest suggesting that, in our study population, the IRS-1 G972R polymorphism does may not appear to be associated with an increased risk of NSCLC.
Files in This Item:
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DOI
10.4046/trd.2009.67.1.8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김세규(Kim, Se Kyu)
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
안철민(Ahn, Chul Min)
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105103
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