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Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans

Authors
 Yumie Rhee  ;  Junho Lee  ;  Ji Young Jung  ;  Jung Eun Lee  ;  So Young Park  ;  Yoo Mee Kim  ;  Sihoon Lee  ;  Han Seok Choi  ;  Se Hwa Kim  ;  Sung-Kil Lim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(2) : 232-236, 2009 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2009
MeSH
Absorptiometry, Photon ; Adult ; Aged ; Aged, 80 and over ; Bone Density/physiology ; Female ; Fractures, Bone/diagnosis ; Fractures, Bone/epidemiology ; Heel/diagnostic imaging ; Humans ; Korea ; Male ; Middle Aged ; Osteoporosis/diagnosis ; Osteoporosis/diagnostic imaging* ; Reference Values ; Risk ; Severity of Illness Index ; Ultrasonography ; Young Adult
Keywords
Demography ; Diagnosis ; Osteoporosis ; Ultrasonography
Abstract
To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans using quantitative ultrasonography (QUS), normative data from 240 females and 238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence estimate for men and women over 50 yr of age was analyzed using previous World Health Organization (WHO) methods and heel QUS. T-scores were calculated from the normative data. There were definite negative correlations between age and all of the QUS parameters, such as speed of sound (SOS), broadband ultrasound attenuation (BUA), and estimated heel bone mineral density (BMD) (p<0.0001). After applying the recently determined prevalence of incident vertebral fracture in Koreans over 50 yr of age (11.6% and 9.1%, female vs male, respectively) to the diagnosis of osteoporosis by T-scores from heel BMD as measured by QUS, it was revealed that applicable T-scores for women and men were -2.25 and -1.85, respectively. These data suggest that simply using a T-score of -2.5, the classical WHO threshold for osteoporosis, underestimates the true prevalence when using peripheral QUS. Further prospective study of the power of QUS in predicting the absolute risk of fracture is needed.
Files in This Item:
T200903467.pdf Download
DOI
10.3346/jkms.2009.24.2.232
Appears in Collections:
5. Research Institutes (연구소) > Institute of Endocrinology (내분비연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hwa(김세화)
Kim, Yoo Mee(김유미)
Park, So Young(박소영)
Lee, Si Hoon(이시훈)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Jun Ho(이준호)
Lim, Sung Kil(임승길)
Choi, Han Seok(최한석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105057
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