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Stimulatory effects of ferulic acid on endurance exercise capacity in mice

Authors
 Yanghee YOU  ;  Jeongjin PARK Ho-Geun YOON  ;  Yoo-Hyun LEE  ;  Kwontack HWANG  ;  Jeongmin LEE  ;  Kyungmi KIM  ;  Kwang-Won LEE  ;  Sangin SHIM  ;  Woojin JUN 
Citation
 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.73(6) : 1392-1397, 2009 
Journal Title
 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 
ISSN
 0916-8451 
Issue Date
2009
MeSH
Animals ; Antioxidants/metabolism ; Coumaric Acids/pharmacology* ; Fatigue/prevention & control ; Glutathione/metabolism ; Liver/metabolism ; Malondialdehyde/metabolism ; Mice ; Physical Conditioning, Animal* ; Physical Endurance*
Keywords
ferulic acid ; exercise endurance capacity ; fatigue ; antioxidation
Abstract
Ferulic acid was orally administered to mice in order to investigate its effects on exercise endurance capacity. When a single administration of ferulic acid was given to the mice in an adjustable-current water pool, the duration of exhaustive swimming was longer than that exhibited by the mice in the control group. Also, when the mice were exhaustively exercised for 3 consecutive days, no change in swimming time was found in the ferulic acid-administered group on the final day, and a large decrease in the untreated mice. Administration of ferulic acid efficiently activated the hepatic antioxidative defense system during exercise. The mice that received ferulic acid showed significant increases in the activity of hepatic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione-S-transferase. Furthermore, an increased glutathione level was observed, while the malondialdehyde content was reduced. These results suggest that ferulic acid possesses stimulatory effects that can enhance exercise endurance capacity and reduce fatigue by elevating antioxidative potentials.
Files in This Item:
T200903370.pdf Download
DOI
10.1271/bbb.90062
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104962
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