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Risk factors of survival and surgical treatment for advanced gastric cancer with large tumor size

Authors
 Chen Li  ;  Sung Jin Oh  ;  Sungsoo Kim  ;  Woo Jin Hyung  ;  Min Yan  ;  Zheng Gang Zhu  ;  Sung Hoon Noh 
Citation
 JOURNAL OF GASTROINTESTINAL SURGERY, Vol.13(5) : 881-885, 2009 
Journal Title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN
 1091-255X 
Issue Date
2009
MeSH
Adult ; Aged ; Cohort Studies ; Female ; Gastrectomy ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/mortality* ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Survival Rate ; Tumor Burden
Keywords
Advanced gastric cancer ; Tumor size ; Surgical treatment
Abstract
BACKGROUND: The purpose of this study was to clarify the clinical significance of tumor size in advanced gastric cancer and to evaluate the risk factors of survival in advanced gastric cancer with large tumor size. METHODS: The cut-off point for tumor size, 90th percentile value of tumor size in advanced gastric cancer, was determined to be 10 cm. We retrospectively studied the clinicopathological features and prognosis of 406 patients with advanced gastric tumors measuring 10 cm or more. RESULTS: Large tumors had a propensity for the following: Borrmann type IV, adjacent organ invasion, lymph node and distant metastasis, and stage IV classification. Tumor size was an independent risk factor for lymph node metastasis and survival in advanced gastric cancer. In patients with large advanced gastric cancer, Borrmann type IV, adjacent organ invasion, and N2-3 nodal involvement were independent factors associated with a poorer prognosis. The 5-year survival rate in large gastric cancer patients without any risk factors (65.5%) was similar with those in small gastric cancer patients (59.3%, P = 0.123). CONCLUSION: Tumor size was a simple predictor for lymph node metastasis and survival in advanced gastric cancer. Radical surgery should be recommended for large advanced gastric cancer patients without risk factors, while large gastric cancer with risk factors may not be a surgically treatable disease.
Full Text
http://link.springer.com/article/10.1007%2Fs11605-009-0800-3
DOI
10.1007/s11605-009-0800-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Oh, Sung Jin(오성진)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104903
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