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Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy.

Authors
 Sang Hoon Han  ;  Bum Sik Chin  ;  Han Sung Lee  ;  Su Jin Jeong  ;  Hee Kyoung Choi  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  Hyun Chul Lee  ;  June Myung Kim 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.58(11) : 1523-1529, 2009 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2009
MeSH
Abdomen/diagnostic imaging ; Adult ; Antiretroviral Therapy, Highly Active* ; Blood Glucose/metabolism ; Blood Pressure/physiology ; Body Composition/drug effects ; Body Composition/physiology ; Cross-Sectional Studies ; Dyslipidemias/blood* ; Dyslipidemias/complications ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV Infections/complications* ; HIV Infections/drug therapy* ; HIV-Associated Lipodystrophy Syndrome/blood ; HIV-Associated Lipodystrophy Syndrome/complications ; Humans ; Insulin Resistance/physiology* ; Lipids/blood ; Male ; Middle Aged ; Obesity/blood* ; Obesity/complications ; RNA, Viral/blood ; Retinol-Binding Proteins, Plasma/metabolism* ; Ultrasonography ; Waist Circumference
Abstract
Highly active antiretroviral therapy (HAART) contributes to the development of metabolic complications including dyslipidemia, insulin resistance (IR), and lipodystrophy (LD). Recent studies reported that retinol-binding protein 4 (RBP4) is associated with IR, dyslipidemia, and obesity in non-HIV-infected populations. The aim of this study was to evaluate the associations between RBP4 and LD or metabolic abnormalities in HIV-infected subjects receiving HAART. We performed a cross-sectional study with 113 HIV-infected subjects receiving HAART for more than 6 months. Body composition and abdominal fat were measured by bioelectrical impedance analysis and ultrasonography, and fasting serum RBP4 was measured by enzyme-linked immunosorbent assay. Retinol-binding protein 4 levels in subjects with LD were similar to those without LD (P = .839). Retinol-binding protein 4 had significantly positive correlations with waist circumference (r = 0.298, P = .002), waist-to-hip ratio (r = 0.336, P = .001), body mass index (r = 0.310, P = .002), total body fat mass (r = 0.323, P = .001), total cholesterol (r = 0.188, P = .048), log (triglyceride) (r = 0.269, P = .004), and log (homeostasis model assessment of IR) (r = 0.207, P = .036), and negative correlations with quantitative insulin sensitivity check index (r = -0.209, P = .034) after adjustment for age and sex. In stepwise multivariate linear regression analysis, waist-to-hip ratio was the most significant independent predictor of increased RBP4 (standardized beta = .351, P = .001). These results suggest that serum RBP4 is associated with obesity, IR, and dyslipidemia in HIV-infected subjects receiving HAART.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049509001620
DOI
10.1016/j.metabol.2009.04.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Han Sung(이한성)
Lee, Hyun Chul(이현철)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104895
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