Cited 13 times in
Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy.
DC Field | Value | Language |
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dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 이한성 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 진범식 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 최희경 | - |
dc.contributor.author | 한상훈 | - |
dc.date.accessioned | 2015-04-24T17:10:25Z | - |
dc.date.available | 2015-04-24T17:10:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104895 | - |
dc.description.abstract | Highly active antiretroviral therapy (HAART) contributes to the development of metabolic complications including dyslipidemia, insulin resistance (IR), and lipodystrophy (LD). Recent studies reported that retinol-binding protein 4 (RBP4) is associated with IR, dyslipidemia, and obesity in non-HIV-infected populations. The aim of this study was to evaluate the associations between RBP4 and LD or metabolic abnormalities in HIV-infected subjects receiving HAART. We performed a cross-sectional study with 113 HIV-infected subjects receiving HAART for more than 6 months. Body composition and abdominal fat were measured by bioelectrical impedance analysis and ultrasonography, and fasting serum RBP4 was measured by enzyme-linked immunosorbent assay. Retinol-binding protein 4 levels in subjects with LD were similar to those without LD (P = .839). Retinol-binding protein 4 had significantly positive correlations with waist circumference (r = 0.298, P = .002), waist-to-hip ratio (r = 0.336, P = .001), body mass index (r = 0.310, P = .002), total body fat mass (r = 0.323, P = .001), total cholesterol (r = 0.188, P = .048), log (triglyceride) (r = 0.269, P = .004), and log (homeostasis model assessment of IR) (r = 0.207, P = .036), and negative correlations with quantitative insulin sensitivity check index (r = -0.209, P = .034) after adjustment for age and sex. In stepwise multivariate linear regression analysis, waist-to-hip ratio was the most significant independent predictor of increased RBP4 (standardized beta = .351, P = .001). These results suggest that serum RBP4 is associated with obesity, IR, and dyslipidemia in HIV-infected subjects receiving HAART. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1523~1529 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Abdomen/diagnostic imaging | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiretroviral Therapy, Highly Active* | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Blood Pressure/physiology | - |
dc.subject.MESH | Body Composition/drug effects | - |
dc.subject.MESH | Body Composition/physiology | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Dyslipidemias/blood* | - |
dc.subject.MESH | Dyslipidemias/complications | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/complications* | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | HIV-Associated Lipodystrophy Syndrome/blood | - |
dc.subject.MESH | HIV-Associated Lipodystrophy Syndrome/complications | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance/physiology* | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/blood* | - |
dc.subject.MESH | Obesity/complications | - |
dc.subject.MESH | RNA, Viral/blood | - |
dc.subject.MESH | Retinol-Binding Proteins, Plasma/metabolism* | - |
dc.subject.MESH | Ultrasonography | - |
dc.subject.MESH | Waist Circumference | - |
dc.title | Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Bum Sik Chin | - |
dc.contributor.googleauthor | Han Sung Lee | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Hee Kyoung Choi | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.1016/j.metabol.2009.04.021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03277 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A03981 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04228 | - |
dc.contributor.localId | A04286 | - |
dc.relation.journalcode | J02223 | - |
dc.identifier.eissn | 1532-8600 | - |
dc.identifier.pmid | 19501863 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0026049509001620 | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Lee, Han Sung | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Chin, Bum Sik | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Choi, Hee Kyoung | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Lee, Han Sung | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Chin, Bum Sik | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Hee Kyoung | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.citation.volume | 58 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1523 | - |
dc.citation.endPage | 1529 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.58(11) : 1523-1529, 2009 | - |
dc.identifier.rimsid | 42558 | - |
dc.type.rims | ART | - |
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