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Modulation of neuropathic pain by galanin and neuropeptide Y at the level of the medulla in rats

Authors
 SE JUNG JUNG  ;  JIN WOO CHANG  ;  RAN WON  ;  MYEOUNG HOON CHA  ;  TAICK SANG NAM  ;  HYE-JUNG LEE  ;  BAE HWAN LEE 
Citation
 INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol.119(10) : 1941-1955, 2009 
Journal Title
 INTERNATIONAL JOURNAL OF NEUROSCIENCE 
ISSN
 0020-7454 
Issue Date
2009
MeSH
Action Potentials/drug effects ; Analysis of Variance ; Animals ; Dose-Response Relationship, Drug ; Eliminative Behavior, Animal ; Galanin/metabolism ; Galanin/pharmacology* ; Galanin/therapeutic use ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Male ; Medulla Oblongata/cytology ; Medulla Oblongata/drug effects* ; Medulla Oblongata/metabolism ; Motor Neurons/drug effects ; Neuralgia/drug therapy ; Neuralgia/metabolism ; Neuralgia/pathology* ; Neuropeptide Y/metabolism ; Neuropeptide Y/pharmacology* ; Neuropeptide Y/therapeutic use ; Pain Measurement/methods ; Pain Threshold/drug effects ; Physical Stimulation ; Rats ; Rats, Sprague-Dawley ; Reaction Time/drug effects
Abstract
This study was conducted to examine the role of galanin and neuropeptide Y (NPY) in the modulation of neuropathic pain at the level of the medulla. Under pentobarbital anesthesia, Sprague-Dawley rats were subjected to neuropathic surgery. Intracisternal injections of galanin and NPY were performed 2 weeks after nerve injury and mechanical allodynia was monitored. In an electrophysiological experiment, rats were reanesthetized with urethane and the responses of gracile nucleus neurons to mechanical stimulation were observed. Galanin and NPY were applied microiontophoretically. Intracisternally administered NPY reduced neuropathic pain behaviors in a dose-dependent manner. High doses of galanin inhibited neuropathic pain behaviors. Iontophoretically ejected galanin and NPY inhibited responses of gracile nucleus neurons to mechanical stimulation. These results suggest that galanin and NPY play a role in modulating neuropathic pain in the gracile nucleus of the medulla.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00207450903263661
DOI
10.1080/00207450903263661
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Se Jung(정세정)
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104869
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