Cited 10 times in
Modulation of neuropathic pain by galanin and neuropeptide Y at the level of the medulla in rats
DC Field | Value | Language |
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dc.contributor.author | 남택상 | - |
dc.contributor.author | 이배환 | - |
dc.contributor.author | 장진우 | - |
dc.contributor.author | 정세정 | - |
dc.contributor.author | 차명훈 | - |
dc.date.accessioned | 2015-04-24T17:09:33Z | - |
dc.date.available | 2015-04-24T17:09:33Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0020-7454 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104869 | - |
dc.description.abstract | This study was conducted to examine the role of galanin and neuropeptide Y (NPY) in the modulation of neuropathic pain at the level of the medulla. Under pentobarbital anesthesia, Sprague-Dawley rats were subjected to neuropathic surgery. Intracisternal injections of galanin and NPY were performed 2 weeks after nerve injury and mechanical allodynia was monitored. In an electrophysiological experiment, rats were reanesthetized with urethane and the responses of gracile nucleus neurons to mechanical stimulation were observed. Galanin and NPY were applied microiontophoretically. Intracisternally administered NPY reduced neuropathic pain behaviors in a dose-dependent manner. High doses of galanin inhibited neuropathic pain behaviors. Iontophoretically ejected galanin and NPY inhibited responses of gracile nucleus neurons to mechanical stimulation. These results suggest that galanin and NPY play a role in modulating neuropathic pain in the gracile nucleus of the medulla. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1941~1955 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Action Potentials/drug effects | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Eliminative Behavior, Animal | - |
dc.subject.MESH | Galanin/metabolism | - |
dc.subject.MESH | Galanin/pharmacology* | - |
dc.subject.MESH | Galanin/therapeutic use | - |
dc.subject.MESH | Hyperalgesia/drug therapy | - |
dc.subject.MESH | Hyperalgesia/etiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medulla Oblongata/cytology | - |
dc.subject.MESH | Medulla Oblongata/drug effects* | - |
dc.subject.MESH | Medulla Oblongata/metabolism | - |
dc.subject.MESH | Motor Neurons/drug effects | - |
dc.subject.MESH | Neuralgia/drug therapy | - |
dc.subject.MESH | Neuralgia/metabolism | - |
dc.subject.MESH | Neuralgia/pathology* | - |
dc.subject.MESH | Neuropeptide Y/metabolism | - |
dc.subject.MESH | Neuropeptide Y/pharmacology* | - |
dc.subject.MESH | Neuropeptide Y/therapeutic use | - |
dc.subject.MESH | Pain Measurement/methods | - |
dc.subject.MESH | Pain Threshold/drug effects | - |
dc.subject.MESH | Physical Stimulation | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reaction Time/drug effects | - |
dc.title | Modulation of neuropathic pain by galanin and neuropeptide Y at the level of the medulla in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | SE JUNG JUNG | - |
dc.contributor.googleauthor | JIN WOO CHANG | - |
dc.contributor.googleauthor | RAN WON | - |
dc.contributor.googleauthor | MYEOUNG HOON CHA | - |
dc.contributor.googleauthor | TAICK SANG NAM | - |
dc.contributor.googleauthor | HYE-JUNG LEE | - |
dc.contributor.googleauthor | BAE HWAN LEE | - |
dc.identifier.doi | 10.1080/00207450903263661 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01271 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03484 | - |
dc.contributor.localId | A03629 | - |
dc.contributor.localId | A03994 | - |
dc.relation.journalcode | J01136 | - |
dc.identifier.eissn | 1563-5279 | - |
dc.identifier.pmid | 19922394 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/00207450903263661 | - |
dc.contributor.alternativeName | Nam, Taick Sang | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.alternativeName | Jung, Se Jung | - |
dc.contributor.alternativeName | Cha, Myeoung Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Taick Sang | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Jung, Se Jung | - |
dc.contributor.affiliatedAuthor | Cha, Myeoung Hoon | - |
dc.citation.volume | 119 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1941 | - |
dc.citation.endPage | 1955 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol.119(10) : 1941-1955, 2009 | - |
dc.identifier.rimsid | 42535 | - |
dc.type.rims | ART | - |
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