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테스토스테론의 대사물인 androsterone의 경련억제에 대한 영향

Other Titles
 The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression 
Authors
 김원주  ;  이수연  ;  조경주  ;  이병인 
Citation
 Journal of the Korean Neurological Association, Vol.27(2) : 142-146, 2009 
Journal Title
Journal of the Korean Neurological Association
ISSN
 1225-7004 
Issue Date
2009
Keywords
Androsterone ; GABA ; Seizure ; Neuroactive steroid
Abstract
Background: Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear. This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy. Methods: The efficacy of androsterone (10~200 mg/kg, i.p.) against seizures induced by various GABA receptor antagonists and glutamate receptor agonists was evaluated. Results: Androsterone protected mice against seizures induced by PTZ (pentylenetetrazol), PCX (picrotoxin), and DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in a dose-dependent manner. Androsterone did not protect against seizures induced by kainic acid, NMDA (N-methyl-D-aspartic acid), or 4-AP (4-aminopyridine) in mice. Conclusions: These results suggest that androsterone exhibits anticonvulsant activity that occurs largely via nongenomic mechanisms. Testosterone-derived androsterone might be an endogenous protective neuroactive steroid in the brain. Key Words: Androsterone, GABA, Seizure, Neuroactive steroid
Files in This Item:
T200903141.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Lee, Byung In(이병인)
Lee, So Yoon(이소윤)
Lee, Su Yeon(이수연)
Cho, Kyuong Joo(조경주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104729
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