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토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과

Other Titles
 The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite 
 구순자  ;  손주연  ;  임현창  ;  엄유정  ;  정의원  ;  김창성  ;  이용근  ;  최성호 
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.39(3) : 321-329, 2009 
Journal Title
Journal of Korean Academy of Periodontology(대한치주과학회지)
Issue Date
bone regeneration ; bone substitutes ; hydroxyapatites
PURPOSE: The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects. METHODS: An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The pecimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation. RESULTS: Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05). CONCLUSIONS: Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Um, Yoo Jung(엄유정)
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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