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Changing prevalence of glomerular diseases in Korean adults: a review of 20 years of experience

Authors
 Jae Hyun Chang  ;  Dong Ki Kim  ;  Hyun Wook Kim  ;  Sun Young Park  ;  Tae-Hyun Yoo  ;  Beom Seok Kim  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Dae-Suk Han  ;  Heon Joo Jeong  ;  Ho Yung Lee 
Citation
 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.24(8) : 2406-2410, 2009 
Journal Title
 NEPHROLOGY DIALYSIS TRANSPLANTATION 
ISSN
 0931-0509 
Issue Date
2009
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Glomerulonephritis/epidemiology* ; Glomerulonephritis/pathology ; Glomerulonephritis, IGA/epidemiology ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, Membranous/epidemiology ; Glomerulonephritis, Membranous/pathology ; Glomerulosclerosis, Focal Segmental/epidemiology ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence ; Prognosis ; Retrospective Studies ; Time Factors ; Young Adult
Abstract
BACKGROUND: The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea. METHODS: Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively. RESULTS: In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9% of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3%), which was followed by minimal change disease (MCD) (15.5%), membranous nephropathy (MN) (12.3%), focal segmental glomerulosclerosis (FSGS) (5.6%) and membranoproliferative GN (MPGN) (4.0%). The most common secondary GN was lupus nephritis (8.7%). The most common idiopathic nephrotic syndrome was MCD (38.5%), which was followed by MN and IgAN. Among 128 (7.4%) patients who were HBsAg-positive, MN (30.5%) and MPGN (21.1%) were the most common GN. When the incidence rates between 1987-91 and 2002-06 were compared, IgAN increased from 25.6 to 34.5%, while MCD (from 23.2 to 7.0%) and MPGN (from 6.7 to 1.7%) decreased significantly (P < 0.01). CONCLUSIONS: IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.
Files in This Item:
T200903027.pdf Download
DOI
10.1093/ndt/gfp091
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Dong Ki(김동기)
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Sun Young(박선영)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Ho Yung(이호영)
Chang, Jae Hyun(장제현)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104604
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