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Effects of Desflurane-Induced Preconditioning Following Ischemia-Reperfusion on Modulation of Calcium Homeostasis in Rat Heart

Authors
 Hyun-Soo Kim  ;  Wyun-Kon Park  ;  Kyung-Bong Yoon 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.6(12) : 1139-1147, 2009 
Journal Title
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1738-2696 
Issue Date
2009
Keywords
Desflurane ; Ca2+ homeostasis ; ischemia-reperfusion
Abstract
Ca2+ overload induced by ischemia-reperfusion alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Although desflurane has been commonly used in anesthesia, little is known about its cardioprotective effect associated with Ca2+ homeostasis in ischemia-reperfused rat heart. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 h of reperfusion. Rats were randomly assigned to one of three groups; Sham, I/R only, desflurane preconditioning group. In the present study, desflurane reduced infarct size (43.6±5.5% vs. 19.1±1.9% for I/R and desflurane, respectively, p<0.01). In desflurane-treated rat heart, we observed a consistent decrease in the expression of pro-apoptotic protein Bax leading to a decrease in cytochrome c release. We also found that desflurane enhanced expression of anti-apoptotic protein Bcl-2, activated ERK concerned with survival, and significantly attenuated abnormal changes of sarcoplasmic reticulum genes and proteins in ischemia-reperfused rat heart. These results suggest that desflurane prevents myocardial injury in response to ischemia-reperfusion by modulating sarcoplasmic reticulum function.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Park, Wyun Kon(박윤곤)
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104578
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