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Effects of Desflurane-Induced Preconditioning Following Ischemia-Reperfusion on Modulation of Calcium Homeostasis in Rat Heart
DC Field | Value | Language |
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dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 윤경봉 | - |
dc.date.accessioned | 2015-04-24T17:00:14Z | - |
dc.date.available | 2015-04-24T17:00:14Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104578 | - |
dc.description.abstract | Ca2+ overload induced by ischemia-reperfusion alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Although desflurane has been commonly used in anesthesia, little is known about its cardioprotective effect associated with Ca2+ homeostasis in ischemia-reperfused rat heart. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 h of reperfusion. Rats were randomly assigned to one of three groups; Sham, I/R only, desflurane preconditioning group. In the present study, desflurane reduced infarct size (43.6±5.5% vs. 19.1±1.9% for I/R and desflurane, respectively, p<0.01). In desflurane-treated rat heart, we observed a consistent decrease in the expression of pro-apoptotic protein Bax leading to a decrease in cytochrome c release. We also found that desflurane enhanced expression of anti-apoptotic protein Bcl-2, activated ERK concerned with survival, and significantly attenuated abnormal changes of sarcoplasmic reticulum genes and proteins in ischemia-reperfused rat heart. These results suggest that desflurane prevents myocardial injury in response to ischemia-reperfusion by modulating sarcoplasmic reticulum function. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1139~1147 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of Desflurane-Induced Preconditioning Following Ischemia-Reperfusion on Modulation of Calcium Homeostasis in Rat Heart | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Hyun-Soo Kim | - |
dc.contributor.googleauthor | Wyun-Kon Park | - |
dc.contributor.googleauthor | Kyung-Bong Yoon | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A02539 | - |
dc.relation.journalcode | J02734 | - |
dc.identifier.eissn | 2212-5469 | - |
dc.subject.keyword | Desflurane | - |
dc.subject.keyword | Ca2+ homeostasis | - |
dc.subject.keyword | ischemia-reperfusion | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Yoon, Kyoung Bong | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Yoon, Kyoung Bong | - |
dc.citation.volume | 6 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1139 | - |
dc.citation.endPage | 1147 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.6(12) : 1139-1147, 2009 | - |
dc.identifier.rimsid | 51121 | - |
dc.type.rims | ART | - |
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