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Cited 3 times in

종양 표적 자기공명 분자영상

Other Titles
 Cancer -Targeted MR Molecular Imaging 
Authors
 송호택  ;  서진석 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, Vol.52(2) : 121-124, 2009 
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지)
ISSN
 1975-8456 
Issue Date
2009
Keywords
Molecular imaging ; Magnetic resonance imaging ; Cancer targeting ; Contrast agent ; Superparamagnetic iron oxide
Abstract
Magnetic resonance (MR) imaging has been widely used in the clinic because of the benefit of high spatial and temporal resolution, and the excellent anatomical tissue contrast. Cancer-targeted MR molecular imaging comprises 3 major components: a relevant molecular target which is specifically highly expressed on the membrane of the cancer cell; a target specific imaging probe which is composed of superparamagnetic iron oxide nanoparticle coreconjugated target specific ligand such as antibody, peptide, and molecules; MR imaging hardware and software which are sensitive to the imaging probe. Among the various molecular targets, HER2/neu receptor antibody, folic acid, and arginine-glycine-aspartic acid (RGD) are well known targeting ligands. The sensitivity of the cancer-targeted MR imaging is affected by the magnetic susceptibility of the T2 contrast agent, resolution of the image, targeting efficiency of the imaging probe, and image acquisition pulse sequence. Recently, successful cancer-targeted MR imaging with T1 contrast agent and cancer-specific molecular MR imaging using innate contrast of the cancer cell by chemical exchange phenomenon without using the imaging probe has been introduced. Cancer-targeted MR molecuar imaging is a robust diagnostic method to detect
cancer at the cellular stage of the cancer development and it would help improve early detection rate of the cancer.
Files in This Item:
T200902982.pdf Download
DOI
10.5124/jkma.2009.52.2.121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104538
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