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Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder

Authors
 Keun-Ah Cheon  ;  Dae-Yeon Cho  ;  Min-Seong Koo  ;  Dong-Ho Song  ;  Kee Namkoong 
Citation
 BIOLOGICAL PSYCHIATRY, Vol.65(7) : 564-570, 2009 
Journal Title
 BIOLOGICAL PSYCHIATRY 
ISSN
 0006-3223 
Issue Date
2009
MeSH
Adolescent ; Alleles ; Attention Deficit Disorder with Hyperactivity/drug therapy* ; Attention Deficit Disorder with Hyperactivity/genetics* ; Central Nervous System Stimulants/therapeutic use* ; Child ; Female ; Homozygote* ; Humans ; Korea ; Male ; Methylphenidate/therapeutic use* ; Polymorphism, Single Nucleotide ; Receptors, Adrenergic, alpha-2/genetics*
Keywords
ADHD ; ADRA2A ; G allele ; methylphenidate ; response
Abstract
BACKGROUND: Methylphenidate (MPH) blocks the norepinephrine transporter as well as the dopamine transporter. The alpha-2a-adrenergic receptor is a key component of the noradrenergic system. The aim of this study was to evaluate the association between the ADRA2A -1291 C>G polymorphism and the response to MPH treatment in Korean subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: This study enrolled 114 ADHD children (mean age = 9.08 +/- 1.94 years) from a child psychiatric clinic in South Korea. Subjects who had an improvement of >/= 50% compared with the baseline ADHD rating scale (ARS) score or who had a Clinical Global Impression-improvement score of 1 or 2 points after treatment were defined as the "good response". We examined the relationship of the ADRA2A to MPH response. RESULTS: We found that a good response to MPH treatment, measured by the ARS as assessed by the parents, was observed for 76.9% of the subjects carrying the G/G genotype but for only 46.0% and 41.7% of those with the C/G and C/C genotypes, respectively [chi(2)(2) = 11.929, p = .003]. We also found a significant difference in the change in total ARS scores between subjects with and without the G/G genotype [t(1) = 2.21, p = .029]. CONCLUSIONS: Our findings provide evidence of an association between the ADRA2A -1291 C>G genotype and response to MPH treatment in Korean subjects with ADHD. Nonetheless, the methodological limitation of not being a randomized placebo-controlled trial and primarily basing results on parent report to clinicians suggest that these results should be viewed as more preliminary.
Full Text
http://www.sciencedirect.com/science/article/pii/S000632230801531X
DOI
10.1016/j.biopsych.2008.12.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104472
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