Cited 35 times in
Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder
DC Field | Value | Language |
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dc.contributor.author | 남궁기 | - |
dc.contributor.author | 송동호 | - |
dc.contributor.author | 천근아 | - |
dc.date.accessioned | 2015-04-24T16:56:55Z | - |
dc.date.available | 2015-04-24T16:56:55Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104472 | - |
dc.description.abstract | BACKGROUND: Methylphenidate (MPH) blocks the norepinephrine transporter as well as the dopamine transporter. The alpha-2a-adrenergic receptor is a key component of the noradrenergic system. The aim of this study was to evaluate the association between the ADRA2A -1291 C>G polymorphism and the response to MPH treatment in Korean subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: This study enrolled 114 ADHD children (mean age = 9.08 +/- 1.94 years) from a child psychiatric clinic in South Korea. Subjects who had an improvement of >/= 50% compared with the baseline ADHD rating scale (ARS) score or who had a Clinical Global Impression-improvement score of 1 or 2 points after treatment were defined as the "good response". We examined the relationship of the ADRA2A to MPH response. RESULTS: We found that a good response to MPH treatment, measured by the ARS as assessed by the parents, was observed for 76.9% of the subjects carrying the G/G genotype but for only 46.0% and 41.7% of those with the C/G and C/C genotypes, respectively [chi(2)(2) = 11.929, p = .003]. We also found a significant difference in the change in total ARS scores between subjects with and without the G/G genotype [t(1) = 2.21, p = .029]. CONCLUSIONS: Our findings provide evidence of an association between the ADRA2A -1291 C>G genotype and response to MPH treatment in Korean subjects with ADHD. Nonetheless, the methodological limitation of not being a randomized placebo-controlled trial and primarily basing results on parent report to clinicians suggest that these results should be viewed as more preliminary. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 564~570 | - |
dc.relation.isPartOf | BIOLOGICAL PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Attention Deficit Disorder with Hyperactivity/drug therapy* | - |
dc.subject.MESH | Attention Deficit Disorder with Hyperactivity/genetics* | - |
dc.subject.MESH | Central Nervous System Stimulants/therapeutic use* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Homozygote* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methylphenidate/therapeutic use* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Receptors, Adrenergic, alpha-2/genetics* | - |
dc.title | Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Keun-Ah Cheon | - |
dc.contributor.googleauthor | Dae-Yeon Cho | - |
dc.contributor.googleauthor | Min-Seong Koo | - |
dc.contributor.googleauthor | Dong-Ho Song | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.identifier.doi | 10.1016/j.biopsych.2008.12.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01240 | - |
dc.contributor.localId | A02018 | - |
dc.contributor.localId | A04027 | - |
dc.relation.journalcode | J00302 | - |
dc.identifier.eissn | 1873-2402 | - |
dc.identifier.pmid | 19150055 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S000632230801531X | - |
dc.subject.keyword | ADHD | - |
dc.subject.keyword | ADRA2A | - |
dc.subject.keyword | G allele | - |
dc.subject.keyword | methylphenidate | - |
dc.subject.keyword | response | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.alternativeName | Song, Dong Ho | - |
dc.contributor.alternativeName | Cheon, Keun Ah | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Song, Dong Ho | - |
dc.contributor.affiliatedAuthor | Cheon, Keun Ah | - |
dc.citation.volume | 65 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 564 | - |
dc.citation.endPage | 570 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL PSYCHIATRY, Vol.65(7) : 564-570, 2009 | - |
dc.identifier.rimsid | 54146 | - |
dc.type.rims | ART | - |
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