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Resistance Trends of Bacteroides fragilis Group Over an 8-Year Period, 1997-2004, in Korea

Other Titles
 국내 분리 Bacteroides fragilis군의 8년간 내성률 변화(1997-2004) 
Authors
 Kyoung Ho Roh  ;  Sinyoung Kim  ;  Chang-Ki Kim  ;  Jong Hwa Yum  ;  Myung Sook Kim  ;  Dongeun Yong  ;  Kyungwon Lee  ;  June Myung Kim  ;  Yunsop Chong 
Citation
 KOREAN JOURNAL OF LABORATORY MEDICINE , Vol.29(4) : 293-298, 2009 
Journal Title
 KOREAN JOURNAL OF LABORATORY MEDICINE 
ISSN
 1598-6535 
Issue Date
2009
MeSH
Anti-Bacterial Agents/pharmacology ; Bacteroides/classification ; Bacteroides/drug effects* ; Bacteroides/isolation & purification ; Bacteroides fragilis/drug effects ; Bacteroides fragilis/isolation & purification ; Cefoxitin/pharmacology ; Chloramphenicol/pharmacology ; Drug Resistance, Multiple, Bacterial* ; Humans ; Imipenem/pharmacology ; Metronidazole/pharmacology ; Microbial Sensitivity Tests ; Penicillanic Acid/analogs & derivatives ; Penicillanic Acid/pharmacology ; Piperacillin/pharmacology ; Republic of Korea
Keywords
Bacteroides fragilis group ; Antimicrobial susceptibility ; Trend ; Korea
Abstract
BACKGROUND: Bacteroides fragilis group organisms are the most frequently isolated anaerobes in human infections. Increasing resistance to various antimicrobial agents is a significant problem in choosing appropriate antimicrobial agents to treat anaerobic infections. Periodic monitoring of the regional resistance trends of B. fragilis group isolates is needed. METHODS: A total of 466 nonduplicate clinical isolates of B. fragilis group organisms (276 B. fragilis, 106 Bacteroides thetaiotaomicron, and 84 other B. fragilis group organisms) were collected during the 8-yr period from 1997 to 2004 in a Korean university hospital. Minimum inhibitory concentrations to various antimicrobial agents were determined by the CLSI agar dilution method. RESULTS: Eight isolates were resistant to imipenem. Additionally, the resistance rates to cefotetan were decreased in B. thetaiotaomicron, while those for clindamycin were significantly increased compared to the rates found in previous studies. Depending on species, resistance rates were 1-4% for imipenem, 1-6% for piperacillin-tazobactam, 4-11% for cefoxitin, 33-49% for piperacillin, 14-60% for cefotetan, and 51-76% for clindamycin. No isolates were resistant to chloramphenicol or metronidazole. CONCLUSIONS: Piperacillin-tazobactam, cefoxitin, imipenem, chloramphenicol, and metronidazole are still active against B. fragilis group isolates, while clindamycin no longer has a value as an empirical therapeutic agent in Korea. Furthermore, this study identified the first imipenem-resistant B. fragilis group isolates in Korea
Files in This Item:
T200902829.pdf Download
DOI
10.3343/kjlm.2009.29.4.293
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Institute of Bacterial Resistance (세균내성연구소) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, June Myung(김준명)
Kim, Chang Ki(김창기)
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104426
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