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Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus

Authors
 SU JIN JEONG  ;  HEEKYUNG CHOI  ;  HAN SUNG LEE  ;  SANG HOON HAN  ;  BUM SIK CHIN  ;  JI-HYEON BAEK  ;  CHANG OH KIM  ;  JUN YONG CHOI  ;  YOUNG GOO SONG  ;  JUNE MYUNG KIM 
Citation
 Scandinavian Journal of Infectious Diseases, Vol.41(4) : 268-274, 2009 
Journal Title
 Scandinavian Journal of Infectious Diseases 
ISSN
 0036-5548 
Issue Date
2009
MeSH
Adult ; Antibodies, Antinuclear/blood ; Case-Control Studies ; Communicable Diseases/epidemiology* ; Communicable Diseases/etiology* ; Complement C3/analysis ; Female ; Humans ; Incidence ; Korea/epidemiology ; Lupus Erythematosus, Systemic/complications* ; Male ; Medical Records ; Retrospective Studies ; Risk Factors
Abstract
Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). This study describes infectious complications in SLE patients and analyzes the risk factors for infection at the time of SLE diagnosis and during the course of SLE in a case-control study. Of 110 patients enrolled, 42 (38%) had at least 1 episode of infectious disease. The incidence of infectious disease was 4.4/100 patient-years (py) with a total follow-up duration of 954 y. In multivariate analysis, independent predictors of infection at the time of SLE diagnosis were an SLE disease activity index (SLEDAI) > 12 (p = 0.01), C3 levels < 90 mg/dl (p = 0.01) and positive anti-ds DNA antibodies (p < 0.01). Frequent flare-ups (p = 0.04) and follow-up duration > or =8 y (p = 0.023) were also significant risk factors for infectious diseases. It is mandatory to closely observe SLE patients with risk factors for developing infectious diseases.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00365540902744741
DOI
10.1080/00365540902744741
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104407
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