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Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus

Authors
 SU JIN JEONG  ;  HEEKYUNG CHOI  ;  HAN SUNG LEE  ;  SANG HOON HAN  ;  BUM SIK CHIN  ;  JI-HYEON BAEK  ;  CHANG OH KIM  ;  JUN YONG CHOI  ;  YOUNG GOO SONG  ;  JUNE MYUNG KIM 
Citation
 Scandinavian Journal of Infectious Diseases, Vol.41(4) : 268-274, 2009 
Journal Title
 Scandinavian Journal of Infectious Diseases 
ISSN
 0036-5548 
Issue Date
2009
Abstract
Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). This study describes infectious complications in SLE patients and analyzes the risk factors for infection at the time of SLE diagnosis and during the course of SLE in a case-control study. Of 110 patients enrolled, 42 (38%) had at least 1 episode of infectious disease. The incidence of infectious disease was 4.4/100 patient-years (py) with a total follow-up duration of 954 y. In multivariate analysis, independent predictors of infection at the time of SLE diagnosis were an SLE disease activity index (SLEDAI) > 12 (p = 0.01), C3 levels < 90 mg/dl (p = 0.01) and positive anti-ds DNA antibodies (p < 0.01). Frequent flare-ups (p = 0.04) and follow-up duration > or =8 y (p = 0.023) were also significant risk factors for infectious diseases. It is mandatory to closely observe SLE patients with risk factors for developing infectious diseases.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00365540902744741
DOI
10.1080/00365540902744741
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
백지현(Baek, Ji Hyeon)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
이한성(Lee, Han Sung)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
진범식(Chin, Bum Sik)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최희경(Choi, Hee Kyoung)
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104407
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