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Comparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage

Authors
 Nam Kyoung Lee  ;  Ho Jung Oh  ;  Choong Man Hong  ;  Hwal Suh  ;  Seung Hwa Hong 
Citation
 BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, Vol.14(2) : 180-186, 2009 
Journal Title
 BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 
ISSN
 1226-8372 
Issue Date
2009
Keywords
artificial cartilage ; biodegradation ; polymer ; chondrocyte ; biocompatibility ; biological safety
Abstract
Chondrocytes are easily de-differentiated when cultured in monolayer, and tissue-engineered cartilage can be generated by seeding chondrocytes onto three-dimensional porous synthetic biodegradable polymers. In this study, we investigated the biochemical and molecular aspects of chondrocytes in a monolayer-culture system and selected the optimal subculture passages based on their de-differentiation. We also compared two commonly used synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA), for their suitability as scaffolds for artificial cartilage. De-differentiated chondrocytes were observed after two passages. These results suggested that the first cell passage was optimal for seeding as only a few chondrocytes secreted extracellular matrix components to form homogeneously compact cartilage. Substantially increased glycosaminoglycan and total collagen levels revealed that PLGA scaffolds were a better option for inducing cartilage tissue formation compared to the PLA scaffolds. Histological and immunohistochemical results showed that chondrocytes seeded into PLGA retained their morphological phenotype to a greater extent than those seeded into PLA
Full Text
http://link.springer.com/article/10.1007%2Fs12257-008-0208-z#
DOI
10.1007/s12257-008-0208-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Suh, Hwal(서활)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104386
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