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Comparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage

DC FieldValueLanguage
dc.contributor.author서활-
dc.date.accessioned2015-04-24T16:54:05Z-
dc.date.available2015-04-24T16:54:05Z-
dc.date.issued2009-
dc.identifier.issn1226-8372-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104386-
dc.description.abstractChondrocytes are easily de-differentiated when cultured in monolayer, and tissue-engineered cartilage can be generated by seeding chondrocytes onto three-dimensional porous synthetic biodegradable polymers. In this study, we investigated the biochemical and molecular aspects of chondrocytes in a monolayer-culture system and selected the optimal subculture passages based on their de-differentiation. We also compared two commonly used synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA), for their suitability as scaffolds for artificial cartilage. De-differentiated chondrocytes were observed after two passages. These results suggested that the first cell passage was optimal for seeding as only a few chondrocytes secreted extracellular matrix components to form homogeneously compact cartilage. Substantially increased glycosaminoglycan and total collagen levels revealed that PLGA scaffolds were a better option for inducing cartilage tissue formation compared to the PLA scaffolds. Histological and immunohistochemical results showed that chondrocytes seeded into PLGA retained their morphological phenotype to a greater extent than those seeded into PLA-
dc.description.statementOfResponsibilityopen-
dc.format.extent180~186-
dc.relation.isPartOfBIOTECHNOLOGY AND BIOPROCESS ENGINEERING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorNam Kyoung Lee-
dc.contributor.googleauthorHo Jung Oh-
dc.contributor.googleauthorChoong Man Hong-
dc.contributor.googleauthorHwal Suh-
dc.contributor.googleauthorSeung Hwa Hong-
dc.identifier.doi10.1007/s12257-008-0208-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01924-
dc.relation.journalcodeJ00334-
dc.identifier.eissn1976-3816-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs12257-008-0208-z#-
dc.subject.keywordartificial cartilage-
dc.subject.keywordbiodegradation-
dc.subject.keywordpolymer-
dc.subject.keywordchondrocyte-
dc.subject.keywordbiocompatibility-
dc.subject.keywordbiological safety-
dc.contributor.alternativeNameSuh, Hwal-
dc.contributor.affiliatedAuthorSuh, Hwal-
dc.citation.volume14-
dc.citation.number2-
dc.citation.startPage180-
dc.citation.endPage186-
dc.identifier.bibliographicCitationBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, Vol.14(2) : 180-186, 2009-
dc.identifier.rimsid53731-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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