Cited 16 times in
Comparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage
DC Field | Value | Language |
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dc.contributor.author | 서활 | - |
dc.date.accessioned | 2015-04-24T16:54:05Z | - |
dc.date.available | 2015-04-24T16:54:05Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104386 | - |
dc.description.abstract | Chondrocytes are easily de-differentiated when cultured in monolayer, and tissue-engineered cartilage can be generated by seeding chondrocytes onto three-dimensional porous synthetic biodegradable polymers. In this study, we investigated the biochemical and molecular aspects of chondrocytes in a monolayer-culture system and selected the optimal subculture passages based on their de-differentiation. We also compared two commonly used synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA), for their suitability as scaffolds for artificial cartilage. De-differentiated chondrocytes were observed after two passages. These results suggested that the first cell passage was optimal for seeding as only a few chondrocytes secreted extracellular matrix components to form homogeneously compact cartilage. Substantially increased glycosaminoglycan and total collagen levels revealed that PLGA scaffolds were a better option for inducing cartilage tissue formation compared to the PLA scaffolds. Histological and immunohistochemical results showed that chondrocytes seeded into PLGA retained their morphological phenotype to a greater extent than those seeded into PLA | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 180~186 | - |
dc.relation.isPartOf | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Comparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | Nam Kyoung Lee | - |
dc.contributor.googleauthor | Ho Jung Oh | - |
dc.contributor.googleauthor | Choong Man Hong | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.contributor.googleauthor | Seung Hwa Hong | - |
dc.identifier.doi | 10.1007/s12257-008-0208-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01924 | - |
dc.relation.journalcode | J00334 | - |
dc.identifier.eissn | 1976-3816 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12257-008-0208-z# | - |
dc.subject.keyword | artificial cartilage | - |
dc.subject.keyword | biodegradation | - |
dc.subject.keyword | polymer | - |
dc.subject.keyword | chondrocyte | - |
dc.subject.keyword | biocompatibility | - |
dc.subject.keyword | biological safety | - |
dc.contributor.alternativeName | Suh, Hwal | - |
dc.contributor.affiliatedAuthor | Suh, Hwal | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 180 | - |
dc.citation.endPage | 186 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, Vol.14(2) : 180-186, 2009 | - |
dc.identifier.rimsid | 53731 | - |
dc.type.rims | ART | - |
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