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15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells

Authors
 Boram Cha  ;  Kyung Hwan Kim  ;  Hyeyoung Kim 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1171 : 457-463, 2009 
Journal Title
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 
ISSN
 0077-8923 
Issue Date
2009
MeSH
Adenocarcinoma/metabolism ; Adenocarcinoma/microbiology ; Adenocarcinoma/pathology ; Antigens, Bacterial/genetics ; Apoptosis/drug effects* ; Bacterial Proteins/genetics ; Blotting, Western ; Cell Line, Tumor ; DNA Fragmentation/drug effects ; Electrophoretic Mobility Shift Assay ; Enzyme-Linked Immunosorbent Assay/methods ; Helicobacter pylori/genetics ; Helicobacter pylori/growth & development* ; Humans ; NF-kappa B/metabolism* ; Oligonucleotides/genetics ; Oligonucleotides/metabolism ; Prostaglandin D2/analogs & derivatives ; Prostaglandin D2/pharmacology ; Protein Binding/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; bcl-2-Associated X Protein/metabolism
Keywords
Helicobacter pylori ; gastric epithelial cells ; apoptosis ; 15d-PGJ2 ; NF-[kappa]B
Abstract
Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-kappaB (NF-kappaB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ(2) inhibits apoptosis by regulating apoptotic gene expression and NF-kappaB activation in gastric epithelial cells infected with CagA+, VacA+H. pylori in a Korean isolate (HP99). 15d-PGJ(2) was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ(2) induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-kappaB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ(2) inhibits apoptotic cell death by inhibiting NF-kappaB activation and apoptotic gene expression in gastric epithelial cells.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04706.x/abstract
DOI
10.1111/j.1749-6632.2009.04706.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104314
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