Cited 5 times in
15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2015-04-24T16:51:46Z | - |
dc.date.available | 2015-04-24T16:51:46Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104314 | - |
dc.description.abstract | Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-kappaB (NF-kappaB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ(2) inhibits apoptosis by regulating apoptotic gene expression and NF-kappaB activation in gastric epithelial cells infected with CagA+, VacA+H. pylori in a Korean isolate (HP99). 15d-PGJ(2) was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ(2) induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-kappaB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ(2) inhibits apoptotic cell death by inhibiting NF-kappaB activation and apoptotic gene expression in gastric epithelial cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 457~463 | - |
dc.relation.isPartOf | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/microbiology | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Antigens, Bacterial/genetics | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | DNA Fragmentation/drug effects | - |
dc.subject.MESH | Electrophoretic Mobility Shift Assay | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods | - |
dc.subject.MESH | Helicobacter pylori/genetics | - |
dc.subject.MESH | Helicobacter pylori/growth & development* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Oligonucleotides/genetics | - |
dc.subject.MESH | Oligonucleotides/metabolism | - |
dc.subject.MESH | Prostaglandin D2/analogs & derivatives | - |
dc.subject.MESH | Prostaglandin D2/pharmacology | - |
dc.subject.MESH | Protein Binding/drug effects | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/microbiology | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | bcl-2-Associated X Protein/metabolism | - |
dc.title | 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Boram Cha | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.identifier.doi | 10.1111/j.1749-6632.2009.04706.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J00181 | - |
dc.identifier.eissn | 1749-6632 | - |
dc.identifier.pmid | 19723089 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04706.x/abstract | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | gastric epithelial cells | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | 15d-PGJ2 | - |
dc.subject.keyword | NF-[kappa]B | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hwan | - |
dc.citation.volume | 1171 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 463 | - |
dc.identifier.bibliographicCitation | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1171 : 457-463, 2009 | - |
dc.identifier.rimsid | 52589 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.