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15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells

DC Field Value Language
dc.contributor.author김경환-
dc.date.accessioned2015-04-24T16:51:46Z-
dc.date.available2015-04-24T16:51:46Z-
dc.date.issued2009-
dc.identifier.issn0077-8923-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104314-
dc.description.abstractHelicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-kappaB (NF-kappaB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ(2) inhibits apoptosis by regulating apoptotic gene expression and NF-kappaB activation in gastric epithelial cells infected with CagA+, VacA+H. pylori in a Korean isolate (HP99). 15d-PGJ(2) was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ(2) induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-kappaB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ(2) inhibits apoptotic cell death by inhibiting NF-kappaB activation and apoptotic gene expression in gastric epithelial cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent457~463-
dc.relation.isPartOfANNALS OF THE NEW YORK ACADEMY OF SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdenocarcinoma/microbiology-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAntigens, Bacterial/genetics-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDNA Fragmentation/drug effects-
dc.subject.MESHElectrophoretic Mobility Shift Assay-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay/methods-
dc.subject.MESHHelicobacter pylori/genetics-
dc.subject.MESHHelicobacter pylori/growth & development*-
dc.subject.MESHHumans-
dc.subject.MESHNF-kappa B/metabolism*-
dc.subject.MESHOligonucleotides/genetics-
dc.subject.MESHOligonucleotides/metabolism-
dc.subject.MESHProstaglandin D2/analogs & derivatives-
dc.subject.MESHProstaglandin D2/pharmacology-
dc.subject.MESHProtein Binding/drug effects-
dc.subject.MESHProto-Oncogene Proteins c-bcl-2/metabolism-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHStomach Neoplasms/microbiology-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHbcl-2-Associated X Protein/metabolism-
dc.title15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorBoram Cha-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorHyeyoung Kim-
dc.identifier.doi10.1111/j.1749-6632.2009.04706.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ00181-
dc.identifier.eissn1749-6632-
dc.identifier.pmid19723089-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04706.x/abstract-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordgastric epithelial cells-
dc.subject.keywordapoptosis-
dc.subject.keyword15d-PGJ2-
dc.subject.keywordNF-[kappa]B-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.citation.volume1171-
dc.citation.startPage457-
dc.citation.endPage463-
dc.identifier.bibliographicCitationANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1171 : 457-463, 2009-
dc.identifier.rimsid52589-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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