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The effect of botulinum toxin A on skin flap survival in rats.

Authors
 Young Seok Kim  ;  Tai Suk Roh  ;  Won-Jai Lee  ;  Won Min Yoo  ;  Kwan-Chul Tark 
Citation
 Wound Repair and Regeneration, Vol.17(3) : 411-417, 2009 
Journal Title
 Wound Repair and Regeneration 
ISSN
 1067-1927 
Issue Date
2009
MeSH
Animals ; Botulinum Toxins, Type A/administration & dosage* ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Graft Survival/drug effects* ; Injections, Intralesional ; Microcirculation/drug effects ; Neurotoxins/administration & dosage ; Pilot Projects ; Rats ; Rats, Sprague-Dawley ; Skin Transplantation/pathology* ; Surgical Flaps/blood supply ; Surgical Flaps/pathology* ; Treatment Outcome ; Vasoconstriction/drug effects ; Wound Healing/drug effects* ; Wound Healing/physiology
Abstract
This study examines the role of botulinum toxin type A (BoTA) in preventing the collapse of the peripheral vessels in the cutaneous flap and in increasing the survival of the flap. Because BoTA cleaves the SNAP-25 protein, the release of vasoconstriction cotransmitters as well as acetylcholine would be blocked. Dorsal skin flaps in rats were elevated and returned to the original position. In the BoTA and the control group, either BoTA or saline was injected into the entire flap. The flap survival rate measurement and a histopathological examination were performed 1 week after flap elevation. The cutaneous blood flow was measured in three different areas of each flap, serially. In BoTA group, there was a significant increase in the survival rate (93.79 +/- 6.06%, p=0.042). In the control group, the blood flow was decreased significantly immediately after flap elevation. The blood flow was high in all areas in the BoTA group in a week, and also most of the vessels maintained their shape without collapsing. In conclusion, pretreatment with BoTA increases the dorsal skin flap survival in rats by increased perfusion, and further studies should be performed to determine the possible mechanism by which BoTA attenuates the sympathetic vasoconstriction effect in skin flaps
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00477.x/abstract
DOI
10.1111/j.1524-475X.2009.00477.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Seok(김영석) ORCID logo https://orcid.org/0000-0002-0981-2107
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Yoo, Won Min(유원민)
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
Tark, Kwan Chul(탁관철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104252
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