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High-density lipoprotein-cholesterol and ischemic heart disease risk in Korean men with cardiac risk

 John A. Linton  ;  Heejin Kimm  ;  Heechoul Ohrr  ;  Il Su Park  ;  Sun Ha Jee 
 CIRCULATION JOURNAL, Vol.73(7) : 1296-1301, 2009 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Cholesterol, HDL/blood* ; Cohort Studies ; Follow-Up Studies ; Humans ; Incidence ; Korea/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Myocardial Infarction/blood* ; Myocardial Infarction/epidemiology* ; Myocardial Ischemia/blood* ; Myocardial Ischemia/epidemiology* ; Outcome Assessment (Health Care) ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Triglycerides/blood
High-density lipoprotein-cholesterol ; Ischemic heart disease ; Myocardial infarction ; Triglyceride
BACKGROUND: Although many epidemiological studies have suggested that a decreased level of high-density lipoprotein-cholesterol (HDL-C) is a risk factor for heart disease; this relationship remains uncertain in relation to triglycerides (TG). This study examined the effects of serum TG and HDL-C on the incidence of ischemic heart disease (IHD) in Korean men.

METHODS AND RESULTS: A 14-year prospective cohort study was carried out with 29,171 Korean men who received insurance from the National Health Insurance Corporation and underwent a second screening for their cardiovascular risks. The main outcome measures were incidence of IHD. During 379,539 person-years of follow-up, 1,634 IHD (227 fatal IHD) events occurred. In the age-adjusted models, men in the lowest level of HDL-C (<30 mg/dl) showed a higher risk [hazard ratio (HR) 1.57; 95% confidence interval (CI) 1.26-1.95] when compared with men with the highest concentration (HDL-C > or =60 g/dl), defined as the reference group. When TG were included in the multivariate adjusted Cox model, the relationship of HDL-C with IHD was weakened but remained (HR 1.38; 95%CI 1.10-1.73). The results were similar for TG in the multivariate model including HDL-C.

CONCLUSIONS: These findings indicate that elevated TG and reduced HDL-C are independent risk factors for IHD risk in Korean men with cardiovascular risks.
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Appears in Collections:
6. Others (기타) > International Health Care Center (국제진료소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Ohrr, Hee Choul(오희철)
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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