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Association between ginseng intake and mortality: Kangwha cohort study

Authors
 Sang-Wook Yi  ;  Jae Woong Sull  ;  Jae Seok Hong  ;  John Alderman Linton  ;  Heechoul Ohrr 
Citation
 JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Vol.15(8) : 921-928, 2009 
Journal Title
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
ISSN
 1075-5535 
Issue Date
2009
MeSH
Aged ; Cardiovascular Diseases/mortality ; Cause of Death ; Cohort Studies ; Female ; Humans ; Korea/epidemiology ; Longevity/drug effects* ; Male ; Middle Aged ; Mortality* ; Multivariate Analysis ; Neoplasms/mortality ; Panax* ; Plant Extracts/administration & dosage* ; Proportional Hazards Models ; Sex Factors ; Survival Analysis
Abstract
OBJECTIVE: Panax ginseng C.A. Meyer is a well-known medicinal herb in North America and Europe. The purpose of this study was to investigate the association between ginseng intake and mortality among members of the Korean population.

METHODS: We followed 6282 subjects who were 55 years of age or older in March 1985 until December 31, 2003. The Cox proportional hazard regression model was used to evaluate effects of ginseng intake on mortality.

RESULTS: Adjusting for age, education, occupation, drinking, smoking, self-reported chronic disease, body mass index, and blood pressure, all-cause mortality for male ginseng users was significantly lower than that for male nonusers (Hazard ratio [HR] = 0.90; 95% confidence interval [CI], 0.81-0.99). However, such an association was not observed in women (HR = 1.03; 95% CI, 0.94-1.13). Cancer-specific mortality was lower in female ginseng users than female nonusers after adjustment of relevant covariates (HR = 0.80; 95% CI, 0.60-1.08). Compared to nonusers, the HR for cancer-specific mortality in women was 0.84 in infrequent users (95% CI, 0.62-1.15) and 0.61 in frequent users (95% CI, 0.32-1.14) (p for trend, 0.09), which is not statistically significant. The cancer-specific mortality was not associated with ginseng intake in male subjects (HR = 0.95; 95% CI, 0.76-1.20). Mortality caused by cardiovascular diseases was not related to ginseng intake in both men and women.

CONCLUSION: The 18.8-year progressive cohort study showed that ginseng intake decreased all-cause mortality in older males, but such life prolongation effect was not shown in women.
Files in This Item:
T200902381.pdf Download
DOI
10.1089/acm.2008.0296
Appears in Collections:
6. Others (기타) > International Health Care Center (국제진료소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Sull, Jae Woong(설재웅)
Ohrr, Hee Choul(오희철)
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
Hong, Jae Seok(홍재석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104137
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