1 330

Cited 46 times in

Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure

Authors
 JAEWON OH  ;  SEOK-MIN KANG  ;  NAMKI HONG  ;  JI-WON CHOI  ;  SANG-HAK LEE  ;  SUNGHA PARK  ;  MIN-JEONG SHIN  ;  YANGSOO JANG  ;  NAMSIK CHUNG 
Citation
 JOURNAL OF CARDIAC FAILURE, Vol.15(6) : 517-522, 2009 
Journal Title
 JOURNAL OF CARDIAC FAILURE 
ISSN
 1071-9164 
Issue Date
2009
MeSH
Acute Disease ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Echocardiography, Doppler, Pulsed*/methods ; Erythrocyte Count/methods ; Erythrocyte Indices/physiology* ; Erythrocytes/metabolism* ; Erythrocytes/pathology* ; Female ; Heart Failure/blood* ; Heart Failure/diagnostic imaging* ; Humans ; Male ; Middle Aged
Keywords
Red cell distribution width ; N-terminal pro-brain natriuretic peptide ; acute heart failure
Abstract
BACKGROUND: Red cell distribution width (RDW) has recently been discovered to be a novel prognostic marker in patients with heart failure. However, the relation between RDW and echocardiographic parameters in acute heart failure (AHF) has not been studied. METHODS AND RESULTS: We analyzed laboratory findings including RDW, N-terminal pro-brain natriuretic peptide (NT-proBNP), and echocardiographic parameters in 100 patients with AHF. The mean RDW was 14.2 +/- 2.0% and median NT-proBNP was 5183 pg/mL. The mean left ventricular ejection fraction was 33.1 +/- 14.5% and early mitral inflow velocity to early diastolic mitral annular velocity (E/E'), was 21.2 +/- 9.4. When the RDW was considered in tertile categories, the highest tertile group (> 14.5%) had higher E/E' (P < .001) and higher NT-proBNP (P = .02) than the lowest tertile group (< 13.2%). In multiple linear regression analysis, RDW was independently correlated with E/E' even after adjustment of other risk factors (beta-coefficient 0.431, P = .001). The optimal cutoff value of RDW for predicting E/E' > 15, suggesting elevated left ventricular filling pressure (LVFP) was 13.45% (area under the curve 0.633, P < .05). An additive power of RDW with NT-proBNP for predicting E/E' > 15 was found in logistic regression analysis (P = .038). CONCLUSIONS: We found a novel relation between higher levels of RDW and elevated E/E' in patients with AHF. This novel finding raises the possibility that a simple marker, RDW may be associated with elevated LVFP in patients with AHF
Full Text
http://www.sciencedirect.com/science/article/pii/S1071916409000165
DOI
10.1016/j.cardfail.2009.01.002
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shin, Min Jeong(신민정)
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104132
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse