239 191

Cited 21 times in

Percutaneous US-guided implantation of Vx-2 carcinoma into rabbit liver: a comparison with open surgical method

Authors
 Kwang-Hun Lee  ;  Eleni Liapi  ;  Manon Buijs  ;  Josephina Anna Vossen  ;  Veronica Prieto-Ventura  ;  Labiq H. Syed  ;  Jean-Francois H. Geschwind 
Citation
 JOURNAL OF SURGICAL RESEARCH, Vol.155(1) : 94-99, 2009 
Journal Title
 JOURNAL OF SURGICAL RESEARCH 
ISSN
 0022-4804 
Issue Date
2009
MeSH
Animals ; Carcinoma* ; Laparotomy ; Liver Neoplasms, Experimental* ; Male ; Neoplasm Transplantation/methods* ; Rabbits ; Ultrasonography, Interventional*
Abstract
PURPOSE: To evaluate technical feasibility and experimental usefulness of percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver. MATERIALS and METHODS: Forty-eight New Zealand White male rabbits were used. Solid tumor mass of Vx-2 carcinoma was harvested from carrier rabbit, and minced tumor cells were implanted. Twenty-four rabbits underwent percutaneous US-guided tumor implantation, and the same number of rabbits underwent open laparotomy tumor implantation. Tested parameters included technical success, procedural time, amount of anesthesia, recovery time, complications, tumor size, and regional tumor seeding. RESULTS: A new percutaneous US-guided implantation was technically feasible in all rabbits. Evaluation parameters showed that the percutaneous US-guided implantation method is less invasive than the open laparotomy method. Targeting rate for left lateral lobe of implantation site was comparable in both methods (91.7% of percutaneous US-guided; 95.8% in open laparotomy). the success rate of tumor growth in the liver was 100% in both groups. However, in the group with US-guidance, tumor seeding developed more frequently in five of 24 rabbits (20.8%) than in open laparotomy group (2/24, 8.3%). Five rabbits had thoracoabdominal wall needle tract seeding, and two rabbits had tumor seeding at both thoracoabdominal wall and intraperitoneal space. CONCLUSIONS: Percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver is a less invasive alternative to open laparotomy, achieving equally successful tumor growth in the liver. Although percutaneous US-guidance implantation method may not be considered for long-term survival study design because of the possibility of tumor seeding, it can be considered for nonsurvival study design.
Files in This Item:
T200902264.pdf Download
DOI
10.1016/j.jss.2008.08.036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hun(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104115
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links