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Peri-operative oral triiodothyronine replacement therapy to prevent postoperative low triiodothyronine state following valvular heart surgery.

 Y. S. Choi  ;  Y. L. Kwak  ;  J. C. Kim  ;  D. H. Chun  ;  S. W. Hong  ;  J. K. Shim 
 ANAESTHESIA, Vol.64(8) : 871-877, 2009 
Journal Title
Issue Date
Administration, Oral ; Adult ; Aged ; Cardiopulmonary Bypass ; Critical Care/methods ; Double-Blind Method ; Drug Administration Schedule ; Euthyroid Sick Syndromes/etiology ; Euthyroid Sick Syndromes/prevention & control* ; Female ; Heart Valves/surgery* ; Hemodynamics ; Hormone Replacement Therapy/methods* ; Humans ; Male ; Middle Aged ; Perioperative Care/methods* ; Postoperative Complications/prevention & control ; Prospective Studies ; Thyroid Hormones/blood ; Triiodothyronine/administration & dosage ; Triiodothyronine/deficiency ; Triiodothyronine/therapeutic use*
This study evaluated the effect of oral triiodothyronine (T(3)) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high-risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T(3) or placebo. In the treatment (T(3)) group patients received 20 microg of oral or nasogastric T(3) every 12 h starting just before induction of anaesthesia and until the first day after surgery. T(3) concentrations were significantly higher in the T(3) group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T(3) group. Significantly fewer patients required vasopressors in the T(3) group on the first day after surgery
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Jong Chan(김종찬)
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Chun, Duk Hee(전덕희)
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
Hong, Seong Wook(홍성욱)
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