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Peri-operative oral triiodothyronine replacement therapy to prevent postoperative low triiodothyronine state following valvular heart surgery.

Authors
 Y. S. Choi  ;  Y. L. Kwak  ;  J. C. Kim  ;  D. H. Chun  ;  S. W. Hong  ;  J. K. Shim 
Citation
 Anaesthesia, Vol.64(8) : 871-877, 2009 
Journal Title
 Anaesthesia 
ISSN
 0003-2409 
Issue Date
2009
Abstract
This study evaluated the effect of oral triiodothyronine (T(3)) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high-risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T(3) or placebo. In the treatment (T(3)) group patients received 20 microg of oral or nasogastric T(3) every 12 h starting just before induction of anaesthesia and until the first day after surgery. T(3) concentrations were significantly higher in the T(3) group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T(3) group. Significantly fewer patients required vasopressors in the T(3) group on the first day after surgery
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2009.05984.x/abstract
DOI
10.1111/j.1365-2044.2009.05984.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
곽영란(Kwak, Young Lan) ORCID logo https://orcid.org/0000-0002-2984-9927
김종찬(Kim, Jong Chan)
심재광(Shim, Jae Kwang) ORCID logo https://orcid.org/0000-0001-9093-9692
전덕희(Chun, Duk Hee)
최용선(Choi, Yong Seon) ORCID logo https://orcid.org/0000-0002-5348-864X
홍성욱(Hong, Seong Wook)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104085
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