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VEGF and activated eosinophils in children with asthma and eosinophilic bronchitis

Other Titles
 소아 천식과 호산구성 기관지염에서 혈관 내피세포 성장인자(VEGF)의 의의 
 Kyung Won Kim  ;  Hye Mi Jee  ;  Kyung Eun Lee  ;  Yeo Hoon Park  ;  Bong Seok Choi  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.19(2) : 173-182, 2009 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
Issue Date
Childhood asthma ; Eosinophil cationic protein ; Eosinophilic bronchitis ; Vascular endothelial growth factor
Purpose: Vascular endothelial growth factor (VEGF) is an important mediator of airway inflammation and remodeling in asthma. We aimed to explore whether VEGF is expressed at elevated levels in asthmatic airways or eosinophilic bronchitis (EB) and associated with eosinophilic inflammation, pulmonary function, and airway hyperresponsiveness (AHR) in children. Methods: One hundred seventeen asthmatic children, 77 children with EB, and 84 healthy children were enrolled. Sputum supernatants were collected and VEGF and eosinophil cationic protein (ECP) levels were measured. Results: Asthmatic children had significantly higher levels of VEGF in induced sputum [89.04 (29.95-178.09) pg/mL] compared to children with EB [25.30 (11.02-80.23) pg/mL] and healthy children [37.37 (16.56-71.30) pg/mL; P=0.0003]. VEGF in sputum positively correlated with sputum ECP (r=0.524; P<0.0001). Negative significant correlations were found between sputum VEGF and FEV1, (r=-0.252; P=0.001) or post-bronchodilator FEV1 (r=-0.181; P=0.038) whereas nonsignificant correlations were found between sputum VEGF and sputum eosinophils. Conclusion: Our findings suggest that VEGF is associated with activated eosinophils in the asthmatic airway, but not EB. Sputum VEGF could be a supportive marker that represents activation of airway eosinophils and persistent airflow limitation in asthmatic children.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Park, Yeo Hoon(박여훈)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Jee, Hye Mi(지혜미)
Choi, Bong Seok(최봉석)
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