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VEGF and activated eosinophils in children with asthma and eosinophilic bronchitis
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 박여훈 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 지혜미 | - |
dc.contributor.author | 최봉석 | - |
dc.date.accessioned | 2015-04-24T16:44:06Z | - |
dc.date.available | 2015-04-24T16:44:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1225-679X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104072 | - |
dc.description.abstract | Purpose: Vascular endothelial growth factor (VEGF) is an important mediator of airway inflammation and remodeling in asthma. We aimed to explore whether VEGF is expressed at elevated levels in asthmatic airways or eosinophilic bronchitis (EB) and associated with eosinophilic inflammation, pulmonary function, and airway hyperresponsiveness (AHR) in children. Methods: One hundred seventeen asthmatic children, 77 children with EB, and 84 healthy children were enrolled. Sputum supernatants were collected and VEGF and eosinophil cationic protein (ECP) levels were measured. Results: Asthmatic children had significantly higher levels of VEGF in induced sputum [89.04 (29.95-178.09) pg/mL] compared to children with EB [25.30 (11.02-80.23) pg/mL] and healthy children [37.37 (16.56-71.30) pg/mL; P=0.0003]. VEGF in sputum positively correlated with sputum ECP (r=0.524; P<0.0001). Negative significant correlations were found between sputum VEGF and FEV1, (r=-0.252; P=0.001) or post-bronchodilator FEV1 (r=-0.181; P=0.038) whereas nonsignificant correlations were found between sputum VEGF and sputum eosinophils. Conclusion: Our findings suggest that VEGF is associated with activated eosinophils in the asthmatic airway, but not EB. Sputum VEGF could be a supportive marker that represents activation of airway eosinophils and persistent airflow limitation in asthmatic children. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 173~182 | - |
dc.relation.isPartOf | Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | VEGF and activated eosinophils in children with asthma and eosinophilic bronchitis | - |
dc.title.alternative | 소아 천식과 호산구성 기관지염에서 혈관 내피세포 성장인자(VEGF)의 의의 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Hye Mi Jee | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Yeo Hoon Park | - |
dc.contributor.googleauthor | Bong Seok Choi | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01558 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A03973 | - |
dc.contributor.localId | A04064 | - |
dc.relation.journalcode | J02476 | - |
dc.subject.keyword | Childhood asthma | - |
dc.subject.keyword | Eosinophil cationic protein | - |
dc.subject.keyword | Eosinophilic bronchitis | - |
dc.subject.keyword | Vascular endothelial growth factor | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Park, Yeo Hoon | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Jee, Hye Mi | - |
dc.contributor.alternativeName | Choi, Bong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Park, Yeo Hoon | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Jee, Hye Mi | - |
dc.contributor.affiliatedAuthor | Choi, Bong Seok | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.19(2) : 173-182, 2009 | - |
dc.identifier.rimsid | 46803 | - |
dc.type.rims | ART | - |
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