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Expression patterns of the Fam83h gene during murine tooth development

Authors
 Min-Jung Lee  ;  Sook-Kyung Lee  ;  Kyung-Eun Lee  ;  Hee-Yun Kang  ;  Han-Sung Jung  ;  Jung-Wook Kim 
Citation
 ARCHIVES OF ORAL BIOLOGY, Vol.54(9) : 846-850, 2009 
Journal Title
 ARCHIVES OF ORAL BIOLOGY 
ISSN
 0003-9969 
Issue Date
2009
MeSH
Alveolar Process/embryology ; Ameloblasts/cytology ; Amelogenesis Imperfecta/genetics* ; Animals ; Dental Enamel/embryology ; Dental Papilla/embryology ; Epithelium/embryology ; Gene Expression Regulation, Developmental/genetics ; In Situ Hybridization ; Incisor/embryology ; Mesoderm/cytology ; Mice ; Mice, Inbred ICR ; Molar/embryology ; Odontoblasts/cytology ; Odontogenesis/genetics* ; Proteins/analysis ; Proteins/genetics* ; Tooth Germ/embryology
Keywords
Fam83h ; Murine ; Tooth ; Ameloblast ; Odontoblast ; Osteoblast ; Enamel ; Dentin
Abstract
AIM: Recently a novel gene, FAM83H, was identified by a genetic linkage study in the hypocalcified form of the amelogenesis imperfecta family with an autosomal dominant hereditary pattern. Little is known about this novel gene, and so we investigated the expression pattern of Fam83h in murine tooth development using serial sectional in situ hybridisation. METHODS AND MATERIALS: Using mandibles of ICR mouse at specific developmental stages, in situ hybridisation was performed by DIG-labeled RNA probe. RESULTS: Faint expression was detected in limited cells at embryonic day 14 (E14) in the molar. At the bell stage, E16, Fam83h was localised in the outer and inner enamel epithelium, as well as dental papilla. Fam83h expression begins on E15 in the developing incisor. At E18, Fam83h was expressed in the inner enamel epithelium of the apical bud, ameloblasts and odontoblasts. The expression was stronger in the presecretory stages than the secretory stages. CONCLUSION: Fam83h was detected in the ameloblasts from the presecretory to the secretory stage, and also the odontoblasts layer and surrounding alveolar bone
Full Text
http://www.sciencedirect.com/science/article/pii/S0003996909001472
DOI
10.1016/j.archoralbio.2009.05.009
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104054
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