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Prediction of recurrence of early gastric cancer after curative resection

Authors
 Ji Fu Lai  ;  Sungsoo Kim  ;  Kiyeol Kim  ;  Chen Li  ;  Sung Jin Oh  ;  Woo Jin Hyung  ;  Sun Young Rha  ;  Hyun Cheol Chung  ;  Seung Ho Choi  ;  Lin Bo Wang  ;  Sung Hoon Noh 
Citation
 Annals of Surgical Oncology, Vol.16(7) : 1896-1902, 2009 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2009
Abstract
BACKGROUND: Recurrence of early gastric cancer (EGC) after curative resection is rare, and the types of EGC that may recur have not been well studied. We attempted to create a system for predicting recurrence of EGC after R0 resection. METHODS: From January 1987 to April 2005, 2,923 patients with EGC who underwent curative resection were retrospectively studied. Of them, 79 patients (2.7%) experienced recurrence. Logistic regression was performed to identify independent risk factors for overall recurrence and early recurrence (recurred within 24 months after resection) of EGC. A nomogram was developed on the basis of a Cox regression. RESULTS: Median time to recurrence was 20.5 months, and early recurrence accounted for 60.7% of instances. Presence of lymph node metastasis and elevated gross type were independent risk factors for overall recurrence; patients with both identified risk factors had a higher recurrence rate than average level (17.5% vs. 2.7%, P < 0.001). Meanwhile, male gender, elevated gross type, and presence of lymph node metastasis were significantly associated with early recurrence, and in patients with all of the aforementioned identified risk factors, the early recurrence rate was higher (12.2% vs. 1.6%, P < 0.001). A nomogram for predicting the disease-free survival after operation was constructed. Its c-index was 0.79 and it appeared to be accurate. CONCLUSIONS: Recurrence of EGC after curative resection can be predicted by using common clinical characteristics. Patients at high risk of overall and early recurrence could be identified; individual disease-free survival was predictable by the internally validated nomogram
Full Text
http://link.springer.com/article/10.1245%2Fs10434-009-0473-x
DOI
10.1245/s10434-009-0473-x
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김기열(Kim, Ki Yeol) ORCID logo https://orcid.org/0000-0001-5357-1067
김성수(Kim, Sung Soo)
노성훈(Noh, Sung Hoon) ORCID logo https://orcid.org/0000-0003-4386-6886
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
오성진(Oh, Sung Jin)
이찬주(Lee, Chan Joo) ORCID logo https://orcid.org/0000-0002-8756-409X
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
최승호(Choi, Seung Ho)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104047
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