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Expression of TGF-β1, MMP-1 and TIMP-1 in irritation fibroma

Other Titles
 자극성 섬유종에서 TGF-β1, MMP-1 및 TIMP-1 발현 
Authors
 Mi Heon Ryu  ;  Baek Il Kim  ;  Hyun Sil Kim  ;  Jin Kim 
Citation
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.33(2) : 61-67, 2009 
Journal Title
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지) 
ISSN
 1225-1577 
Issue Date
2009
Keywords
Irritation fibroma ; Wound healing process ; TGF-β1 ; MMP-1 ; TIMP-1 ; Proliferative activity
Abstract
Irritation fibroma(IF) is the most common tumor-like lesion. IF is characterized by over-production of collagen and, thus, resembles scar tissue. TGF-β1, MMP and TIMP play an essential role in remodeling extracellular matrix during scar formation. This study investigates the pathogenesis of IF with respect to the coordinated expression of factors involved in wound healing. Proliferative activity and expression of TGF-β1, MMP-1 and TIMP-1 were observed using immunohistochemistry in 88 cases of IF and 9 cases of normal oral mucosa(NOM). Proliferative activity and expression of TGF-β1 and TIMP-1 were increased in IF compared to NOM. MMP-1 expression was not significantly increased in IF. We propose that IF is caused by increased expression of TGF-β1 and an imbalance in expression of MMP-1 and TIMP-1.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Kim, Jin(김진)
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103983
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