344 385

Cited 0 times in

Expression of TGF-β1, MMP-1 and TIMP-1 in irritation fibroma

DC FieldValueLanguage
dc.contributor.author김백일-
dc.contributor.author김진-
dc.contributor.author김현실-
dc.date.accessioned2015-04-24T16:41:15Z-
dc.date.available2015-04-24T16:41:15Z-
dc.date.issued2009-
dc.identifier.issn1225-1577-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103983-
dc.description.abstractIrritation fibroma(IF) is the most common tumor-like lesion. IF is characterized by over-production of collagen and, thus, resembles scar tissue. TGF-β1, MMP and TIMP play an essential role in remodeling extracellular matrix during scar formation. This study investigates the pathogenesis of IF with respect to the coordinated expression of factors involved in wound healing. Proliferative activity and expression of TGF-β1, MMP-1 and TIMP-1 were observed using immunohistochemistry in 88 cases of IF and 9 cases of normal oral mucosa(NOM). Proliferative activity and expression of TGF-β1 and TIMP-1 were increased in IF compared to NOM. MMP-1 expression was not significantly increased in IF. We propose that IF is caused by increased expression of TGF-β1 and an imbalance in expression of MMP-1 and TIMP-1.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExpression of TGF-β1, MMP-1 and TIMP-1 in irritation fibroma-
dc.title.alternative자극성 섬유종에서 TGF-β1, MMP-1 및 TIMP-1 발현-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Preventive Dentistry (예방치과학)-
dc.contributor.googleauthorMi Heon Ryu-
dc.contributor.googleauthorBaek Il Kim-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorJin Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00485-
dc.contributor.localIdA01121-
dc.contributor.localIdA02466-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ02084-
dc.subject.keywordIrritation fibroma-
dc.subject.keywordWound healing process-
dc.subject.keywordTGF-β1-
dc.subject.keywordMMP-1-
dc.subject.keywordTIMP-1-
dc.subject.keywordProliferative activity-
dc.contributor.alternativeNameKim, Baek Il-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameRyu, Mi Heon-
dc.contributor.affiliatedAuthorKim, Baek Il-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.contributor.affiliatedAuthorRyu, Mi Heon-
dc.contributor.affiliatedAuthorKim, Jin-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage61-
dc.citation.endPage67-
dc.identifier.bibliographicCitationKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.33(2) : 61-67, 2009-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.