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Circulating IL-8 levels in heart failure patients with and without metabolic syndrome

Authors
 Min-Jeong Shin  ;  Kyung Hye Lee  ;  Ji Hyung Chung  ;  Yoo Kyoung Park  ;  Mi Kyung Choi  ;  Jaewon Oh  ;  Ji Won Choi  ;  Sang-Hak Lee  ;  Namsik Chung  ;  Seok-Min Kang 
Citation
 CLINICA CHIMICA ACTA, Vol.405(1-2) : 139-142, 2009 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2009
MeSH
Blood Glucose/metabolism ; C-Reactive Protein/metabolism ; Female ; Heart Failure/blood* ; Heart Failure/complications* ; Humans ; Interleukin-8/blood* ; Lipoproteins/blood ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/complications* ; Middle Aged
Keywords
Heart failure ; Metabolic syndrome ; C-reactive protein ; Interleukin-8
Abstract
BACKGROUND: It has been suggested that the metabolic syndrome (MetS) is associated with increased risk for heart failure (HF) and progression of HF. However, the underlying mechanisms are unclear. We tested whether the presence of the MetS would be associated with the increased degree of inflammatory state in HF. METHODS: Ninety-one eligible consecutive stable HF patients participated in this cross-sectional study. Anthropometric measurements were carried out and serum concentrations of lipoproteins, apolipoproteins (apoB, apoAI) and high sensitivity C-reactive protein (hsCRP) were measured. The simultaneous measurement of 17 cytokines using bioplex analysis was used. RESULT: Thirty-five subjects (39% of total, 48% of males and 31% of females) were classified as having the MetS in total HF patients. Serum concentrations of apoB (p<0.005) were significantly higher and the ratio of apoAI and apoB was significantly lower (p<0.01) in HF patients with MetS than those without MetS. Plasma levels of IL-8 (p<0.05) were significantly higher in HF patients with MetS than those without MetS. In addition, serum concentrations of hsCRP (p<0.005) were significantly higher in HF patients with MetS compared to those without MetS. CONCLUSIONS: The MetS in HF is associated with increased degree of inflammation, which provides information regarding the relationship between inflammation and HF with MetS.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898109002253
DOI
10.1016/j.cca.2009.04.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Chung, Nam Sik(정남식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103913
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