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Quantification and characterization of obstructive coronary plaques using 64-slice computed tomography: a comparison with intravascular ultrasound

Authors
 Jin Hur  ;  Young Jin Kim  ;  Hye-Jeong Lee  ;  Ji Eun Nam  ;  Kyu Ok Choe  ;  Jae Seung Seo  ;  Dong-Hoon Choi  ;  Jung-Sun Kim  ;  Byoung Wook Choi 
Citation
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, Vol.33(2) : 186-192, 2009 
Journal Title
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 
ISSN
 0363-8715 
Issue Date
2009
MeSH
Coronary Angiography/statistics & numerical data* ; Coronary Stenosis/diagnostic imaging* ; Coronary Vessels/diagnostic imaging* ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed/statistics & numerical data* ; Ultrasonography
Keywords
computed tomographic coronary angiography ; intravascular ultrasound ; coronary plaque ; quantification ; composition
Abstract
PURPOSE: The aim of this study was to determine the diagnostic accuracy of 64-slice computed tomography (CT) coronary angiography in the quantification and characterization of obstructive coronary plaques in comparison with intravascular ultrasound (IVUS). MATERIALS AND METHODS: Thirty-nine patients were selected who underwent both CT coronary angiography (CTCA) and IVUS. For each stenotic site (n = 61), the maximum vessel cross-sectional area, lumen cross-sectional area, plaque area, and percentage of luminal obstruction were measured. Plaque composition was analyzed according to IVUS (plaque echogenicity and classified into several types: calcified, mixed, fibrous, and soft plaques) and CTCA criteria (Hounsfield units [HU]). The correlation between CTCA and IVUS measurements was determined using Pearson correlation coefficient. The statistical significance of differences in the CT densities of plaques among plaque types determined by IVUS was assessed using the Scheffe method. RESULTS: The correlation coefficients for the measurements of the lumen, vessel, plaque area, and percentage of luminal obstruction were r = 0.712, r = 0.654, r = 0.753, and r = 0.799, respectively. The mean CT density values for soft (n = 10), fibrous (n = 11), mixed (n = 31), and calcified plaques (n = 9) were 54 +/- 13 HU, 82 +/- 17 HU, 162 +/- 57 HU, and 392 +/- 155 HU, respectively. Computed tomography density measurements were not significantly different between soft and fibrous plaques (P = 0.224). CONCLUSIONS: Sixty-four-slice CTCA is a noninvasive modality that allows quantification of coronary artery plaques. However, reliable classification of noncalcified plaques as vulnerable or stable plaques based on CT density measurements is currently limited.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004728-200903000-00005&LSLINK=80&D=ovft
DOI
10.1097/RCT.0b013e31817c420f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Nam, Ji Eun(남지은)
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choe, Kyu Ok(최규옥)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103869
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