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Characteristics of ethylnitrosourea-induced cataracts

Authors
 Min-Jung Lee  ;  Jae-Young Kim  ;  Yeun-Jung Kim  ;  Jae-Woo Cho  ;  Kyu-Hyuk Cho  ;  Chang-Woo Song  ;  Han-Sung Jung 
Citation
 CURRENT EYE RESEARCH, Vol.34(5) : 360-368, 2009 
Journal Title
 CURRENT EYE RESEARCH 
ISSN
 0271-3683 
Issue Date
2009
MeSH
Animals ; Cataract/chemically induced* ; Cataract/genetics ; Cataract/metabolism ; Cataract/pathology ; Connexins/genetics ; Crystallins/genetics ; Crystallins/metabolism ; DNA Mutational Analysis ; Electrophoresis, Gel, Two-Dimensional ; Ethylnitrosourea* ; Eye Proteins/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Phenotype ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Array Analysis ; Tissue Distribution
Abstract
PURPOSE: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. MATERIALS AND METHODS: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. RESULTS: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. CONCLUSIONS: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse
Full Text
http://informahealthcare.com/doi/abs/10.1080/02713680902843047
DOI
10.1080/02713680902843047
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103803
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