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Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma

Authors
 Jaeho Cho  ;  Joong-Uhn Choi  ;  Dong-Seok Kim  ;  Chang-Ok Suh 
Citation
 RADIOTHERAPY AND ONCOLOGY, Vol.91(1) : 75-79, 2009 
Journal Title
 RADIOTHERAPY AND ONCOLOGY 
ISSN
 0167-8140 
Issue Date
2009
MeSH
Adolescent ; Adult ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy* ; Child ; Child, Preschool ; Cranial Irradiation/methods* ; Female ; Follow-Up Studies ; Germinoma/pathology ; Germinoma/radiotherapy* ; Humans ; Male ; Neoplasm Recurrence, Local ; Quality of Life ; Radiotherapy Dosage ; Survival Rate ; Treatment Outcome
Keywords
Intracranial germinoma ; Optimal radiotherapy ; Craniospinal irradiation
Abstract
PURPOSE: To determine the optimal radiotherapy (RT) dose and volume for treatment of intracranial germinoma. MATERIALS AND METHODS: Eighty-one intracranial germinoma patients (33 pathologically-verified; 48 presumed by radiosensitivity testing) treated with RT alone between 1971 and 2002 were analyzed. The RT volume varied from focal (13) to whole brain (8), or to the entire neuraxis (60). All the cases after 1982 received craniospinal irradiation (CSI). Radiation dose was reduced gradually during the study period from 59 to 39.3 Gy for primary tumors, and from 34.2 to 19.5 Gy for the neuraxis. The median follow-up time was 120 months (48-260 months). RESULTS: Five- and ten-year relapse-free survival rates were 98.8% and 94.1%, respectively. All the recurrences occurred in the patients who received local (4/13) or whole brain RT (1/8). None of the patients who received CSI suffered from a recurrence. Forty-six patients received 45 Gy or less to the primary site and 22 patients received less than 20 Gy to the spinal axis. CONCLUSION: Low-dose CSI-based RT should remain the standard treatment for intracranial germinoma. The RT dose can be reduced to 39.3 Gy for primary tumor sites and to 19.5 Gy for the spinal axis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167814008005653
DOI
10.1016/j.radonc.2008.10.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Suh, Chang Ok(서창옥)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Choi, Joong Uhn(최중언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103749
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