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G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

DC FieldValueLanguage
dc.contributor.author권우선-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author안중배-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2015-04-24T16:33:03Z-
dc.date.available2015-04-24T16:33:03Z-
dc.date.issued2009-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103724-
dc.description.abstractAt 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p=0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p=0.018). A higher IC(50) was found in GG than GT/A genotype (p=0.02) and in G-C than G-T haplotype (p=0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p=0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHATP Binding Cassette Transporter, Sub-Family B-
dc.subject.MESHATP-Binding Cassette, Sub-Family B, Member 1/genetics*-
dc.subject.MESHAntineoplastic Agents, Phytogenic/pharmacology*-
dc.subject.MESHAsian Continental Ancestry Group*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDrug Resistance, Neoplasm-
dc.subject.MESHGeneExpressionProfiling-
dc.subject.MESHHaplotypes*-
dc.subject.MESHHumans-
dc.subject.MESHPaclitaxel/pharmacology*-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.titleG-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorWoo Sun Kwon-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorJae Joon Jung-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.identifier.doi10.1016/j.canlet.2008.12.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00240-
dc.contributor.localIdA01281-
dc.contributor.localIdA02262-
dc.contributor.localIdA03712-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid19138818-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383508009300-
dc.subject.keywordABCB1-
dc.subject.keywordG–T haplotype-
dc.subject.keywordPaclitaxel sensitivity-
dc.subject.keywordExpression profile-
dc.contributor.alternativeNameKwon, Woo Sun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChung, Jae Joon-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorKwon, Woo Sun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChung, Jae Joon-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume277-
dc.citation.number2-
dc.citation.startPage155-
dc.citation.endPage163-
dc.identifier.bibliographicCitationCANCER LETTERS, Vol.277(2) : 155-163, 2009-
dc.identifier.rimsid36653-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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