Cited 13 times in
G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern
DC Field | Value | Language |
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dc.contributor.author | 권우선 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2015-04-24T16:33:03Z | - |
dc.date.available | 2015-04-24T16:33:03Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103724 | - |
dc.description.abstract | At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p=0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p=0.018). A higher IC(50) was found in GG than GT/A genotype (p=0.02) and in G-C than G-T haplotype (p=0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p=0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Sub-Family B | - |
dc.subject.MESH | ATP-Binding Cassette, Sub-Family B, Member 1/genetics* | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology* | - |
dc.subject.MESH | Asian Continental Ancestry Group* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Drug Resistance, Neoplasm | - |
dc.subject.MESH | GeneExpressionProfiling | - |
dc.subject.MESH | Haplotypes* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Paclitaxel/pharmacology* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.title | G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Woo Sun Kwon | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Jae Joon Jung | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1016/j.canlet.2008.12.001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00240 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03712 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 19138818 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383508009300 | - |
dc.subject.keyword | ABCB1 | - |
dc.subject.keyword | G–T haplotype | - |
dc.subject.keyword | Paclitaxel sensitivity | - |
dc.subject.keyword | Expression profile | - |
dc.contributor.alternativeName | Kwon, Woo Sun | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Chung, Jae Joon | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Kwon, Woo Sun | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Chung, Jae Joon | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 277 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.277(2) : 155-163, 2009 | - |
dc.identifier.rimsid | 36653 | - |
dc.type.rims | ART | - |
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