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Therapy-related acute lymphoblastic leukemia with t(9;22)(q34;q11.2):a case study and review of the literature

Authors
 Sang-Guk Lee  ;  Jong Rak Choi  ;  Jin Seok Kim  ;  Tae Sung Park  ;  Kyung-A Lee  ;  Jaewoo Song 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.191(1) : 51-54, 2009 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2009
MeSH
Biopsy, Fine-Needle ; Bone Marrow/pathology ; Chromosomes, Human, Pair 22/genetics* ; Chromosomes, Human, Pair 9/genetics* ; Female ; Humans ; Karyotyping ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics* ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Translocation, Genetic*
Abstract
Therapy-related acute lymphoblastic leukemia (t-ALL) with t(9;22)(q34;q11.2) is rarely reported as a secondary malignant neoplasm. To our knowledge, only 10 Ph+ t-ALL cases have been reported in the literature. However, 8/10 cases were not reported individually but constituted parts of larger studies reporting cytogenetic abnormalities in secondary leukemia. Snyder et al. first reported Ph+ t-ALL in two patients who had been treated successfully for Ewing sarcoma. We present a novel case of t-ALL with t(9;22) in a patient with primary breast cancer. The interval between diagnosis of breast cancer and the appearance of ALL was 4 years. The patient was treated with partial mastectomy and axillary lymph node dissection followed by six cycles of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy and radiation therapy. Bone metastases were found 3 years after surgery, and she was treated with epirubicin and paclitaxel. This case has the following unique features: BCR/ABL gene rearrangement in t-ALL, and two types of malignant cells (leukemic lymphoblasts and metastatic breast cancer cells) coexisted in the bone marrow.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460809000843
DOI
10.1016/j.cancergencyto.2009.02.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103706
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