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Therapy-related acute lymphoblastic leukemia with t(9;22)(q34;q11.2):a case study and review of the literature

DC Field Value Language
dc.contributor.author김진석-
dc.contributor.author박태성-
dc.contributor.author송재우-
dc.contributor.author이경아-
dc.contributor.author최종락-
dc.contributor.author이상국-
dc.date.accessioned2015-04-24T16:32:29Z-
dc.date.available2015-04-24T16:32:29Z-
dc.date.issued2009-
dc.identifier.issn0165-4608-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103706-
dc.description.abstractTherapy-related acute lymphoblastic leukemia (t-ALL) with t(9;22)(q34;q11.2) is rarely reported as a secondary malignant neoplasm. To our knowledge, only 10 Ph+ t-ALL cases have been reported in the literature. However, 8/10 cases were not reported individually but constituted parts of larger studies reporting cytogenetic abnormalities in secondary leukemia. Snyder et al. first reported Ph+ t-ALL in two patients who had been treated successfully for Ewing sarcoma. We present a novel case of t-ALL with t(9;22) in a patient with primary breast cancer. The interval between diagnosis of breast cancer and the appearance of ALL was 4 years. The patient was treated with partial mastectomy and axillary lymph node dissection followed by six cycles of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy and radiation therapy. Bone metastases were found 3 years after surgery, and she was treated with epirubicin and paclitaxel. This case has the following unique features: BCR/ABL gene rearrangement in t-ALL, and two types of malignant cells (leukemic lymphoblasts and metastatic breast cancer cells) coexisted in the bone marrow.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER GENETICS AND CYTOGENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHBone Marrow/pathology-
dc.subject.MESHChromosomes, Human, Pair 22/genetics*-
dc.subject.MESHChromosomes, Human, Pair 9/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaryotyping-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrecursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy*-
dc.subject.MESHPrecursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*-
dc.subject.MESHPrecursor Cell Lymphoblastic Leukemia-Lymphoma/pathology-
dc.subject.MESHTranslocation, Genetic*-
dc.titleTherapy-related acute lymphoblastic leukemia with t(9;22)(q34;q11.2):a case study and review of the literature-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSang-Guk Lee-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorTae Sung Park-
dc.contributor.googleauthorKyung-A Lee-
dc.contributor.googleauthorJaewoo Song-
dc.identifier.doi10.1016/j.cancergencyto.2009.02.002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01017-
dc.contributor.localIdA01725-
dc.contributor.localIdA02054-
dc.contributor.localIdA02647-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ00443-
dc.identifier.eissn1873-4456-
dc.identifier.pmid19389510-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0165460809000843-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNamePark, Tae Sung-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.alternativeNameLee, Kyung A-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorPark, Tae Sung-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorLee, Kyung A-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.citation.volume191-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage54-
dc.identifier.bibliographicCitationCANCER GENETICS AND CYTOGENETICS , Vol.191(1) : 51-54, 2009-
dc.identifier.rimsid36639-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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