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Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas

Authors
 SUNG P. HONG  ;  EUN K. LEE  ;  JEONG Y. PARK  ;  TAE J. JEON  ;  SEUNGMIN BANG  ;  SEUNGWOO PARK  ;  JAE B. CHUNG  ;  WOO J. LEE  ;  HOGUEN KIM  ;  SI Y. SONG 
Citation
 ONCOLOGY REPORTS, Vol.21(1) : 19-24, 2009 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
2009
MeSH
Adenocarcinoma, Mucinous/metabolism ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Papillary/metabolism ; Adenocarcinoma, Papillary/pathology ; Adult ; Aged ; Biomarkers, Tumor/analysis* ; Carcinoma, Pancreatic Ductal/metabolism* ; Carcinoma, Pancreatic Ductal/pathology ; Epidermal Growth Factor/biosynthesis* ; Female ; GPI-Linked Proteins ; Gene Expression ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins ; Male ; Membrane Glycoproteins/biosynthesis* ; Middle Aged ; Neoplasm Proteins/biosynthesis* ; Pancreatic Neoplasms/metabolism* ; Pancreatic Neoplasms/pathology ; Reverse Transcriptase Polymerase Chain Reaction
Abstract
Human Cripto-1, a membrane-bound protein, plays an important role during early embryogenesis and has oncogenic properties, including cell transformation and enhancement of invasion. Cripto-1 is up-regulated in various malignant tissues and premalignant lesions. However, Cripto-1 expression in intraductal papillary mucinous neoplasms (IPMNs) has yet to be reported. This study aimed to investigate Cripto-1 expression in IPMNs and evaluate the expression patterns according to the histological grade or phenotypic subclassification. Cripto-1 expression was evaluated by immunohistochemistry using 37 IPMN tissue samples and real-time RT-PCR analysis of seven frozen samples. Cripto-1 was up-regulated in 59.5% of IPMNs. Cripto-1 was positively stained in 3 of 4 (75%) adenomas, 12 of 19 (63.2%) borderline neoplasms, 5 of 11 (45.5%) non-invasive carcinomas and 2 of 3 (66.7%) invasive carcinomas. There was no correlation between Cripto-1 overexpression and the histological grade (P>0.05). Cripto-1 expression was significantly increased in pancreatobiliary- (4/5, 80%) and gastric-type (13/19, 68.4.2%) IPMNs compared with those of the intestinal type (2/10, 20%; P<0.01). Cripto-1 mRNA expression was higher in gastric- and pancreatobiliary-type IPMNs than in intestinal ones, supporting the immunohistochemical results. It is concluded that Cripto-1 overexpression is involved in the tumorigenesis of gastric- and pancreatobiliary-type IPMNs.
Full Text
http://www.spandidos-publications.com/or/21/1/19?text=abstract
DOI
10.3892/or_00000184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Ho Keun(김호근)
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Lee, Eun Kyung(이은경)
Chung, Jae Bock(정재복)
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103543
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