Cited 8 times in
Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas
DC Field | Value | Language |
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dc.contributor.author | 이은경 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 홍성필 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이우정 | - |
dc.date.accessioned | 2015-04-24T16:27:19Z | - |
dc.date.available | 2015-04-24T16:27:19Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103543 | - |
dc.description.abstract | Human Cripto-1, a membrane-bound protein, plays an important role during early embryogenesis and has oncogenic properties, including cell transformation and enhancement of invasion. Cripto-1 is up-regulated in various malignant tissues and premalignant lesions. However, Cripto-1 expression in intraductal papillary mucinous neoplasms (IPMNs) has yet to be reported. This study aimed to investigate Cripto-1 expression in IPMNs and evaluate the expression patterns according to the histological grade or phenotypic subclassification. Cripto-1 expression was evaluated by immunohistochemistry using 37 IPMN tissue samples and real-time RT-PCR analysis of seven frozen samples. Cripto-1 was up-regulated in 59.5% of IPMNs. Cripto-1 was positively stained in 3 of 4 (75%) adenomas, 12 of 19 (63.2%) borderline neoplasms, 5 of 11 (45.5%) non-invasive carcinomas and 2 of 3 (66.7%) invasive carcinomas. There was no correlation between Cripto-1 overexpression and the histological grade (P>0.05). Cripto-1 expression was significantly increased in pancreatobiliary- (4/5, 80%) and gastric-type (13/19, 68.4.2%) IPMNs compared with those of the intestinal type (2/10, 20%; P<0.01). Cripto-1 mRNA expression was higher in gastric- and pancreatobiliary-type IPMNs than in intestinal ones, supporting the immunohistochemical results. It is concluded that Cripto-1 overexpression is involved in the tumorigenesis of gastric- and pancreatobiliary-type IPMNs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 19~24 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/metabolism | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/pathology | - |
dc.subject.MESH | Adenocarcinoma, Papillary/metabolism | - |
dc.subject.MESH | Adenocarcinoma, Papillary/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/metabolism* | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/pathology | - |
dc.subject.MESH | Epidermal Growth Factor/biosynthesis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | GPI-Linked Proteins | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/biosynthesis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins/biosynthesis* | - |
dc.subject.MESH | Pancreatic Neoplasms/metabolism* | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.title | Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | SUNG P. HONG | - |
dc.contributor.googleauthor | EUN K. LEE | - |
dc.contributor.googleauthor | JEONG Y. PARK | - |
dc.contributor.googleauthor | TAE J. JEON | - |
dc.contributor.googleauthor | SEUNGMIN BANG | - |
dc.contributor.googleauthor | SEUNGWOO PARK | - |
dc.contributor.googleauthor | JAE B. CHUNG | - |
dc.contributor.googleauthor | WOO J. LEE | - |
dc.contributor.googleauthor | HOGUEN KIM | - |
dc.contributor.googleauthor | SI Y. SONG | - |
dc.identifier.doi | 10.3892/or_00000184 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03033 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A02993 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 19082438 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/21/1/19?text=abstract | - |
dc.contributor.alternativeName | Lee, Eun Kyung | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Lee, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 24 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.21(1) : 19-24, 2009 | - |
dc.identifier.rimsid | 37916 | - |
dc.type.rims | ART | - |
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