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A case of combined hepatocellular-cholangiocarcinoma with favorable response to systemic chemotherapy

 Gun Min Kim  ;  Hei-Cheul Jeung  ;  Dokyung Kim  ;  Joo Hoon Kim  ;  Sang Hyun Yoon  ;  Eun Suk Jung  ;  Sang Joon Shin 
 CANCER RESEARCH AND TREATMENT, Vol.42(4) : 235-238, 2010 
Journal Title
Issue Date
Cholangiocarcinoma ; Cisplatin ; Doxorubicin ; Hepatocellular carcinoma
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare form of primary liver cancer composed of cells with histopathologic features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Because of its low incidence, the information on clinical outcomes of cHCC-CC is very limited and there are no published reports describing non-surgical treatment options for cHCC-CC. We report a case of cHCC-CC exhibiting a favorable response to systemic chemotherapy with doxorubicin and cisplatin. A 62-year-old man who recurred after a right lobectomy for cHCC-CC received sorafenib for palliative systemic therapy, but follow up imaging studies showed disease progression. He received 2nd line chemotherapy with doxorubicin at 60 mg/m(2) together with cisplatin at 70 mg/m(2). After 2 cycles of chemotherapy, a computed tomography scan of the chest showed markedly decreased size and number of the multiple lung metastases. After completing 8 cycles of 2nd line therapy, we changed the regimen to a fluorouracil (5-FU) mono therapy because of the toxicities associated with doxorubicin and cisplatin. To date, the patient has completed his 15th cycle of 5-FU mono therapy with the disease status remaining stable during 18 months of follow-up.
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1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gun Min(김건민) ORCID logo https://orcid.org/0000-0001-9167-8682
Kim, Joo Hoon(김주훈)
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Yoon, Sang Hyun(윤상현)
Jung, Eun Suk(정은석)
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
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