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A case of combined hepatocellular-cholangiocarcinoma with favorable response to systemic chemotherapy

DC FieldValueLanguage
dc.contributor.author김건민-
dc.contributor.author김주훈-
dc.contributor.author신상준-
dc.contributor.author윤상현-
dc.contributor.author정은석-
dc.contributor.author정희철-
dc.date.accessioned2015-04-23T17:50:26Z-
dc.date.available2015-04-23T17:50:26Z-
dc.date.issued2010-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103235-
dc.description.abstractCombined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare form of primary liver cancer composed of cells with histopathologic features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Because of its low incidence, the information on clinical outcomes of cHCC-CC is very limited and there are no published reports describing non-surgical treatment options for cHCC-CC. We report a case of cHCC-CC exhibiting a favorable response to systemic chemotherapy with doxorubicin and cisplatin. A 62-year-old man who recurred after a right lobectomy for cHCC-CC received sorafenib for palliative systemic therapy, but follow up imaging studies showed disease progression. He received 2nd line chemotherapy with doxorubicin at 60 mg/m(2) together with cisplatin at 70 mg/m(2). After 2 cycles of chemotherapy, a computed tomography scan of the chest showed markedly decreased size and number of the multiple lung metastases. After completing 8 cycles of 2nd line therapy, we changed the regimen to a fluorouracil (5-FU) mono therapy because of the toxicities associated with doxorubicin and cisplatin. To date, the patient has completed his 15th cycle of 5-FU mono therapy with the disease status remaining stable during 18 months of follow-up.-
dc.description.statementOfResponsibilityopen-
dc.format.extent235~238-
dc.relation.isPartOfCancer Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA case of combined hepatocellular-cholangiocarcinoma with favorable response to systemic chemotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorGun Min Kim-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorDokyung Kim-
dc.contributor.googleauthorJoo Hoon Kim-
dc.contributor.googleauthorSang Hyun Yoon-
dc.contributor.googleauthorEun Suk Jung-
dc.contributor.googleauthorSang Joon Shin-
dc.identifier.doi10.4143/crt.2010.42.4.235-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00287-
dc.contributor.localIdA00949-
dc.contributor.localIdA02105-
dc.contributor.localIdA02561-
dc.contributor.localIdA03794-
dc.contributor.localIdA03686-
dc.relation.journalcodeJ00453-
dc.identifier.pmid21253326-
dc.subject.keywordCholangiocarcinoma-
dc.subject.keywordCisplatin-
dc.subject.keywordDoxorubicin-
dc.subject.keywordHepatocellular carcinoma-
dc.contributor.alternativeNameKim, Gun Min-
dc.contributor.alternativeNameKim, Joo Hoon-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameYoon, Sang Hyun-
dc.contributor.alternativeNameJung, Eun Suk-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorKim, Gun Min-
dc.contributor.affiliatedAuthorKim, Joo Hoon-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorYoon, Sang Hyun-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorJung, Eun Suk-
dc.citation.volume42-
dc.citation.number4-
dc.citation.startPage235-
dc.citation.endPage238-
dc.identifier.bibliographicCitationCancer Research and Treatment, Vol.42(4) : 235-238, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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