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18F-FDG PET imaging of progressive massive fibrosis

 Soo Yoon Chung  ;  Jae Hoon Lee  ;  Tae Hoon Kim  ;  Sang Jin Kim  ;  Hyung Joong Kim  ;  Young Hoon Ryu 
 ANNALS OF NUCLEAR MEDICINE, Vol.24(1) : 21-27, 2010 
Journal Title
Issue Date
Aged ; Biopsy, Fine-Needle ; Diagnosis, Differential ; Female ; Fibrosis ; Fluorodeoxyglucose F18* ; Follow-Up Studies ; Humans ; Lung/diagnostic imaging* ; Lung/pathology* ; Lung Neoplasms/complications ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Positron-Emission Tomography ; Radiography, Thoracic ; Retrospective Studies ; Tomography, X-Ray Computed
Progressive massive fibrosis ; Pneumoconiosis ; Lung cancer ; 18F-FDG PET ; Chest CT
PURPOSE: This study was to evaluate (18)F-FDG PET features of progressive massive fibrosis (PMF) and to determine the ability of FDG PET to differentiate pure PMF from PMF-associated lung cancer. METHODS: (18)F-FDG PET and chest computed tomography (CT) scans were performed in 9 patients with pneumoconiosis and PMF. Patients who showed active pulmonary tuberculosis on CT scan were excluded. Pure PMF was confirmed via either fine needle aspiration biopsy (n = 6) or 12 months follow-up CT scan (n = 3). CT features and PET findings were evaluated for distribution of fibrotic masses, consolidations, and nodules on CT scan and mean and maximum standardized uptake values (SUVs) of abnormalities depicted on PET scan. RESULTS: 14 masses were detected from nine patients. On chest CT scan, PMF masses were noted with surrounding small nodules and distortion of parenchyma. The size of the lesions ranged from 1.2 to 6.4 cm in maximum diameter. FDG PET scans identified metabolically active lesions in all patients. Maximal SUV ranged from 3.1 to 14.6 and mean SUV ranged from 1.4 to 8.5. CONCLUSION: FDG PET can identify PMF lesions as hypermetabolic lesions even without associated malignancy or tuberculosis. Therefore, it might have a limited role in the diagnosis of PMF with possible concurrent granulomatous inflammation or lung cancer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Jin(김상진)
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Chung, Soo Yoon(정수윤) ORCID logo https://orcid.org/0000-0002-6751-7288
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