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지역 사회에 거주하는 건강한 노인 여성에서 한 계절에 측정한 비타민 D(25-hydroxyvitamin D) 및 DHEA-S와 우울증과의 상관 관계

Other Titles
 Serum 25-hydroxyvitamin D and DHEA-S Level Are Associated with Depression in Community-dwelling Older Women: Surveyed in One Season 
 김현미  ;  이지연  ;  정지연  ;  이덕철 
 Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.11(4) : 332-340, 2010 
Journal Title
 Korean Journal of Clinical Geriatrics (임상노인의학회지) 
Issue Date
25-hydroxyvitamin D ; 25-OH-Vitamin D ; DHEA-S ; Dehydroepiandrosterone-sulfate ; Depressive disorder ; Depression
Background: Even some previous studies suggested that vitamin D deficiency may contribute to depressive disorder, the association between vitamin D deficiency and depression has been controversial. Furthermore, only few studies have done in general population. Dehydroepiandrosterone-sulfate (DHEA-S) is most abundant steroid hormone secreted by adrenal cortex, known to have diverse role in human includingstabilizing mood. Aim of this study was to investigate the association between serum 25-hydroxyvitmin D and DHEA-S and depression in community dwelling apparently healthy women. Methods: This study conducted as a part of the Yonsei Aging Study (YAS). YAS was designed as a survey to investigate the factors related to depression, cognitive function and physical performance in community dwelling old people in Korea. A total of 136 women aged older than 60 years. Blood sample is obtained in October and November in 2008. Depressive symptoms are assessed by self-reported by Geriatric depression scale-15 (GDS-15). Depressive disorder is defined as a GDS-15 score of 7 or higher. Cognitive abilities were assessed using the Mini-Mental State Examination (MMSE). Additionally, cardiometabolic risk factors, DHEA-S and 25-(OH) vitamin D level and physical performance index (by gait speed, chair stand test, and tandem standing test) were measured. Results: The prevalence of depression was vitamin D deficiency is 46.3% in this study population. Mean values of 25(OH) vitamin D and DHEA-S (18.47±7.10 ng/mL, 52.98±31.96 μg/dL respectively) in women with depression were lower than those in normal women (22.01±8.09 ng/mL, 44.58±32.54 μg/dL respectively; P<0.02, P=0.12 respectively). The prevalence of vitamin deficiency (25-hydroxy vitamin D <10 ng/mL) and vitamin insufficiency (25-hydroxy vitamin D <20 ng/mL) were 6.62% and 46.32% respectively. Correlation analysis showed GDS scores associated with 25-(OH) vitamin D level (r=−0.26, P<0.005), physical performance index (r=−0.22, P<0.01), and DHEA-S level (−0.20, P <0.05). Women with history of diabetes mellitus and current smoking habit had a higher prevalence of depression in statistical significance. A Multiple linear regression analysis showed that 25(OH) vitamin D level was an independent risk factor for depression after adjustment for confounding variables. Conclusion: This study suggested that 25-hydroxy vitamin D and DHEA-S levels are the independently associated with depression in apparently healthy community-dwelling older women.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
Chung, Ji Youn(정지연)
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