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크립토코쿠스 수막염 : 일개 대학병원에서 최근 12년간의 경험

Other Titles
 Cryptococcal Meningitis : 12 Years Experience in a Single Tertiary Health Care Center 
Authors
 Su Jin Jeong  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Ji-hyeon Baek  ;  Bum Sik Chin  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
Citation
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.42(5) : 285-290, 2010 
Journal Title
 INFECTION AND CHEMOTHERAPY (감염과 화학요법) 
ISSN
 1598-8112 
Issue Date
2010
Keywords
Cryptococcal infection ; Cryptococcal meningitis ; Fever
Abstract
BACKGROUND: Cryptococcal infections are frequent in human immunodeficiency virus (HIV)-infected patients. This infection may occur in other immunocompromised patients, and the diagnosis is often delayed in these cases. There are a few reports on cryptococcal meningitis in non-HIV-infected patients in Korea. We reviewed the clinical features and efficacy of antifungal therapy in 33 patients who were treated at a single tertiary health care center of Korea. MATERIALS AND METHODS: The medical records of 33 consecutive patients who were admitted to one tertiary hospital for cryptococcal meningitis between 1995 and 2008 were reviewed retrospectively. Cryptococcal meningitis was confirmed by positive cerebral spinal fluid (CSF) cultures or compatible clinical features plus a positive cryptococcal antigen test of CSF. RESULTS: Of the 33 patients analyzed, 30 cases were non-HIV patients. The outcomes were complete cure in 23 cases, relapse after initial treatment in four cases, and death due to treatment failure in six cases. The main initial manifestations were headache (84.8%), fever (54.5%), and seizure (33.3%). Factors significantly associated with unfavorable outcomes, including mortality and relapse, were afebrile condition, mental change, hearing impairment, initial high opening pressure of CSF (>250 mmH2O), and low initial absolute neutrophil count. On multivariate analysis, afebrile condition was an independent predictor of an unfavorable outcome (odds ratio 17.3; 95% confidence interval 1.0-28.3; P=0.045). CONCLUSIONS: It is necessary to observe closely cryptococcal meningitis patients without fever on admission
Files in This Item:
T201005034.pdf Download
DOI
10.3947/ic.2010.42.5.285
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Jin, Sung Joon(진성준)
Chae, Yun Tae(채윤태)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102929
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